ABSTRACT:
Breast cancer is a disease that can be described as malignant cells from the breast tissues. Immune deregulation has been postulated to be one of the mechanisms underlying the pathogenesis of breast cancer. The current study is planned to shed light on the following profiles and identify the relationships serum levels of CXCR4 among obesity postmenopausal, and Breast cancer. This study hypothesized that CXCR4 level would have a link with breast cancer patients. The serum CXCR4 level was measured by enzyme-linked immunosorbent assay (ELISA) in breast cancer patients (n=60) and healthy controls (n=61). The observations indicate a significant increase (P =0.05) in breast cancer patient’s serum levels of CXCR4 compared with healthy control. The study also presented a significant difference among age and Body Mass Index (BMI) between patients and control groups. The results supported that the immune disturbance is related tobreast cancer patients and might play an important role in the pathophysiology of breast cancer.