Author(s): Sneha Jagtap, Chandrakant Magdum

Email(s): snehajagtap22@rediffmail.com

DOI: 10.5958/0974-360X.2019.00614.0   

Address: Sneha Jagtap*1, Chandrakant Magdum2
1Annasaheb Dange College of B Pharmacy, Ashta, Sangli - 416301 Maharashtra, India.
2Rajarambapu College of Pharmacy, Kasegaon, Sangli -415404 Maharashtra, India.
*Corresponding Author

Published In:   Volume - 12,      Issue - 8,     Year - 2019


ABSTRACT:
The study reported in this current work objected to demonstrate the formation of binary and ternary inclusion complexes of Epalrestat (EP), a poorly water-soluble acidic type drug, with ß-cyclodextrin (CD) and with water-soluble polymers PVP K30 and HPMC E4. The solid systems of EP with ß-CD and water-soluble polymers were obtained by kneading and characterized for phase solubility, saturation solubility, dissolution, stability studies. FTIR, DSC, PXRD and SEM data indicated the positive influence of ß-CD and hydrophilic polymers on EP solubility and dissolution. Phase solubility studies were carried out to evaluate the solubilizing power of CD, with regards to EP in combination with water-soluble polymers, and to determine the apparent stability constants (Ks) and complexation efficiency (CE) of the complexes. Phase solubility studies showed AL (linear) type of solubility curve for the ternary complexes it also showed amelioration in Ks value for ternary complexes. The CE of ß-CD towards EP was promoted by water-soluble polymers signifying its use as a ternary component. The dissolution rate of EP and solubility were undoubtedly improved by complexation with ß-CD as compared to model drug EP alone. Ternary complexes incorporated with PVP K 30 and HPMC E4 proved better than binary complex. Hence, the water-soluble carrier could be exploited as a ternary component to improve the solubility of EP via ß-CD complexation.


Cite this article:
Sneha Jagtap, Chandrakant Magdum. Influence of Water-soluble polymers on Epalrestat ternary complexation by kneading. Research J. Pharm. and Tech 2019; 12(8): 3602-3608. doi: 10.5958/0974-360X.2019.00614.0

Cite(Electronic):
Sneha Jagtap, Chandrakant Magdum. Influence of Water-soluble polymers on Epalrestat ternary complexation by kneading. Research J. Pharm. and Tech 2019; 12(8): 3602-3608. doi: 10.5958/0974-360X.2019.00614.0   Available on: https://rjptonline.org/AbstractView.aspx?PID=2019-12-8-4


Recomonded Articles:

Author(s): Hitendra Choudhary, Bhagwan Yadav, Pankaj Patel, Prabhat Das, Sujit Pillai

DOI: 10.5958/0974-360X.2019.00645.0         Access: Open Access Read More

Author(s): Chapalamadugu Ugandhar

DOI: Not Available         Access: Open Access Read More

Author(s): Pankaj P. Ostwal, Yogesh L. Jadhav, Mayur S. Jain, Sumit P. Jain

DOI: Not Available         Access: Open Access Read More

Author(s): Bhupen Kalita, Malay K. Das, Anil Kumar Sharma

DOI: Not Available         Access: Open Access Read More

Author(s): Bibaswan Mishra, Biswaranjan Mohanty, Chandra Sekhar Barik

DOI: 10.5958/0974-360X.2019.00450.5         Access: Open Access Read More

Author(s): Abdul Hasan Sathali. A, Jeya Chandra Prakash. S.K.

DOI: 10.5958/0974-360X.2015.00235.8         Access: Open Access Read More

Author(s): S. Duraivel, V. Venkateswarlu, Ammula Praveen Kumar, Harish Gopinath

DOI: Not Available         Access: Open Access Read More

Author(s): Dasari Nirmala, P.Ashok Chakradhar, M. Sudhakar

DOI: 10.5958/0974-360X.2016.00105.0         Access: Open Access Read More

Author(s): Keshav R. Deshmukh, Alok Pandey, Ashish Pandey, Vidyanand Patel, Shekhar Verma, Pramod Dewangan, Ghanshyam Deshmukh

DOI: Not Available         Access: Open Access Read More

Author(s): Manivannan Rangasamy, Ayyasamy Balasubramaniam, Sandeep Gummadevelly

DOI:         Access: Open Access Read More

Author(s): Mahore J. G., Deshkar S. S., Kumare P. P.

DOI: 10.5958/0974-360X.2019.00276.2         Access: Open Access Read More

Author(s): Siva Prasad Sunkara, Vidyadhara Suryadevara, Sowjanya Lakshmi Bathula, Sandeep Doppalapudi, Pavan Kumar Padarthi, Viswanadh Kunam

DOI: 10.5958/0974-360X.2020.00142.0         Access: Open Access Read More

Author(s): Peenal Gangotia, Shweta Nehate, Hitesh Jain, D. B. Meshram

DOI: 0.5958/0974-360X.2019.00305.6         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags