ABSTRACT:
The present report describes the synthesis of 1,3,4-oxadiazole compounds on shiff base substituted on creatinine ring, the Synthetic route started from reaction shiff base derivatives with a-chloroethylacetate to give compounds(1e-2e). Hydrazide derivatives were synthesized by the reaction compounds (1e-2e) with hydrazine hydrate to give compounds (3e-4e). The compounds (3e-4e) reacts with phenylisothiocyanate to give compounds (5e-6e). The synthesized compounds characterized by FT-IR and1HNMRspectroscopy.Beside the experimental work, we worked theoretical study involving calculated the spectra, total energy, dipole moment etc. Also this study was designed to show the effects of creatinine derivatives on the activities of some transferase enzymes such as: GOT, and GPT enzymes in sera. This compounds demonstrated activation effects on GOT and GPT activities. These effects increased with increasing the concentration of the compounds. The causes of the increases in the enzymes activities are discussed.