Author(s): Sumit Kumar, Badruddeen, S. P. Singh, Akhtar Juber, Mohammad Irfan Khan

Email(s): badarmiracle@gmail.com

DOI: 10.5958/0974-360X.2019.00598.5   

Address: Sumit Kumar1, Badruddeen2*, S. P. Singh1, Akhtar Juber2, Mohammad Irfan Khan2
1Department of Pharmacology and Therapeutics, GSVM Medical College, Kanpur (U.P), India.
2Faculty of Pharmacy, Integral University, Lucknow (U.P), India.
*Corresponding Author

Published In:   Volume - 12,      Issue - 7,     Year - 2019


ABSTRACT:
In clinical practice dermatological reactions are common but comprehensive information regarding their incidence, severity is often not available as many cases go unreported. The objective of this study was to evaluate the types of dermatological adverse drug reactions (ADRs) in a tertiary care hospital and determine their causal relationship with the offending drug. This prospective, observational study was conducted at GSVM medical college Kanpur, Northern India for one year. Patients of all age and either sex were included. Dermatological adverse drug reactions were reported by the physicians of various department of the hospital and their causality assessments were performed as per World health organization (WHO) Uppsala monitoring centre (UMC), Expanded Rawlins and Thompson’s classification was used for determining type of ADRs, outcome and seriousness of ADR were assessed as per WHO. Descriptive statistics were used for data analysis. A total of 105 dermatological adverse drug reactions were reported from various departments of this tertiary care hospital. Most of the adverse drug reactions were observed in the age group of 0–20 year. Rash (35 ADRs) was commonly reported reaction. Anticancer drugs lead to 48 ADRs (mainly with Paclitaxel+Carboplatin-11, Adriamycin+Cyclophosphamide-7), followed by Antibacterial with 28 ADRs (mainly with Vancomycin-6, Cefixime-4 and Amoxicillin-4). A total of 8 ADRs were of serious type mainly with Vancomycin-Red man syndrome-6, Carbamazepine-toxic epidermal necrolysis-1 and Nimesulide-Steven Johnson Syndrome-1. Most of the adverse drug reactions on causality assessment were possible (77, 73.33%) and Probable (28, 26.67%) in nature. Type -B ADRs account for 2/3rd of the total dermatological ADRs. It’s highly emphasized for careful monitoring for ADRs associated with high risk drugs and more awareness should be created.


Cite this article:
Sumit Kumar, Badruddeen, S. P. Singh, Akhtar Juber, Mohammad Irfan Khan. Evaluation of Dermatological Adverse Drug Reactions in a Tertiary Care Hospital of Northern India. Research J. Pharm. and Tech. 2019; 12(7): 3517-3521. doi: 10.5958/0974-360X.2019.00598.5

Cite(Electronic):
Sumit Kumar, Badruddeen, S. P. Singh, Akhtar Juber, Mohammad Irfan Khan. Evaluation of Dermatological Adverse Drug Reactions in a Tertiary Care Hospital of Northern India. Research J. Pharm. and Tech. 2019; 12(7): 3517-3521. doi: 10.5958/0974-360X.2019.00598.5   Available on: https://rjptonline.org/AbstractView.aspx?PID=2019-12-7-73


Recomonded Articles:

Author(s): Loveleen Preet Kaur, Rajeev Garg, GD Gupta

DOI: Not Available         Access: Open Access Read More

Author(s): Suchithra. A. B, S. Jeganath, E. Jeevitha

DOI: 10.5958/0974-360X.2019.01073.4         Access: Open Access Read More

Author(s): Yasmin A, Vijaya Bharathi R, Radha R

DOI: 10.5958/0974-360X.2019.00429.3         Access: Open Access Read More

Author(s): Ankur Choubey, Hemant Kumar, Shelesh Jain

DOI: 10.5958/0974-360X.2020.00962.2         Access: Open Access Read More

Author(s): Meenakshi K, Safa M, Karthick T, Sivaranjani N

DOI: 10.5958/0974-360X.2017.00253.0         Access: Open Access Read More

Author(s): Yarnykh T.G., Azarenko Iu. M., Buryak M.V., Bubilieva L. A.

DOI: 10.5958/0974-360X.2016.00115.3         Access: Open Access Read More

Author(s): Anshu Sharma, CP Jain, MS Ashawat

DOI:         Access: Open Access Read More

Author(s): Mahadeva Rao U.S., Suganya M. Utharkar, C. Shanmuga Sundaram

DOI: 10.5958/0974-360X.2015.00307.8         Access: Open Access Read More

Author(s): B. Venkateswarlu, A. V. S. N. Murty

DOI: 10.5958/0974-360X.2016.00447.9         Access: Open Access Read More

Author(s): K. Gnanaprakash, K.B. Chandhra Shekhar, C. Madhu Sudhana Chetty

DOI: Not Available         Access: Open Access Read More

Author(s): Sarumathy S., CH Haripriya, Muddala Vara Prasanna Rao, Gayathri K., CH Bala Sudhakar, Divya M., Shanmugasundaram P.

DOI: 10.5958/0974-360X.2015.00272.3         Access: Open Access Read More

Author(s): Asija Rajesh, Patel Pinkesh, Asija Sangeeta

DOI: Not Available         Access: Open Access Read More

Author(s): Akiladevi D, Hari Prakash, Biju Gb, Madumitha N

DOI: 10.5958/0974-360X.2020.00183.3         Access: Open Access Read More

Author(s): R. Pandian , Lalitha Kumari

DOI: 10.5958/0974-360X.2016.00471.6         Access: Open Access Read More

Author(s): Ramadevi Bhimavarapu, Ramesetti RamaDevi, Srinath Nissankararao, Chaitanya Devarapalli, Sowjanya Paparaju

DOI: Not Available         Access: Open Access Read More

Author(s): A Pavan Kumar, J Satyanaryana, V Sai Kishore, TE Gopala Krishna Murthy

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags