Author(s): Debi Prasad Pradhan, Mukthinuthalapati Mathrusri Annapurna

Email(s): debi.rips@gmail.com

DOI: 10.5958/0974-360X.2019.00582.1   

Address: Debi Prasad Pradhan, Mukthinuthalapati Mathrusri Annapurna
Department of Pharmaceutical Analysis & Quality Assurance, GITAM Institute of Pharmacy, GITAM
(Deemed to be University), Visakhapatnam, Andhra Pradesh-530045, India.
*Corresponding Author

Published In:   Volume - 12,      Issue - 7,     Year - 2019


ABSTRACT:
Racecadotril is an anti-diarrheal drug. Waters Alliance e2695 with PDA detector (2998) Zorbax SB C18 column (150 x 4.6 mm, 3.5 µm) (Isocratic mode) was used for the quantification of Racecadotril. A mixture of water and Acetonitrile (50:50) was used as diluent and the injection volume was 20 µl. The flow rate was 1.0mL/min (Detection wave length 230 nm). Linearity was evaluated in the concentration range 1-360 µg/ml with regression equation y = 14710 x+9958.9(Correlation coefficient R² = 0.9996). The LOD and LOQ were found to be 0.2942 µg/mL and 0.9694 µg/mL respectively. Forced degradation studies were conducted for Racecadotril capsules and method validation was performed as per ICH guidelines.


Cite this article:
Debi Prasad Pradhan, Mukthinuthalapati Mathrusri Annapurna. Stability indicating LC-TQ-ESI-MS method for the quantification of Racecadotril in presence of its degradants. Research J. Pharm. and Tech. 2019; 12(7):3437-3443. doi: 10.5958/0974-360X.2019.00582.1

Cite(Electronic):
Debi Prasad Pradhan, Mukthinuthalapati Mathrusri Annapurna. Stability indicating LC-TQ-ESI-MS method for the quantification of Racecadotril in presence of its degradants. Research J. Pharm. and Tech. 2019; 12(7):3437-3443. doi: 10.5958/0974-360X.2019.00582.1   Available on: https://rjptonline.org/AbstractView.aspx?PID=2019-12-7-57


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DOI: 10.5958/0974-360X 

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