Author(s): Balakrishnan Purushothaman, Nagarasan Suganthi, Arunachalam Jothi, Kumaran Shanmugam

Email(s): Email ID Not Available

DOI: 10.5958/0974-360X.2019.00579.1   

Address: Balakrishnan Purushothaman1,2*, Nagarasan Suganthi 2, Arunachalam Jothi3, Kumaran Shanmugam1
1Department of Biotechnology, Periyar Maniammai Institute of Science and Technology, Thanjavur – 613403, Tamilnadu, India.
2Tan Bio R and D Solution, Periyar Technology Business Incubator, Vallam, Thanjavur – 613403, Tamilnadu, India.
3Department of Bioinformatics, School of Chemical and Biotechnology, SASTRA University, Thanjavur – 613 401, Tamilnadu, India.
*Corresponding Author

Published In:   Volume - 12,      Issue - 7,     Year - 2019


ABSTRACT:
Colorectal cancer (CRC) ranks third in cancer deaths all over the world. Mortality and incidence rates of CRC in India is constantly increasing due to change in food habits, life style etc., Ocimum basilicum has been reported for constituents like eugenol, germacrene, gurjunene, menthol and ß-elemene with anticancer properties. As an initiative, these chemical constituents were studied against human colorectal biomarkers such as KRAS, NRAS, BRAF (Oncogenes); PIK3CA, P53, DCC (Tumor suppressor genes) through molecular docking. Autodock 4.2 software was used to understand the drug-biomolecular interactions; binding mechanism of drug (ligand) and receptor (target); binding energy and bond length. The mutant type proteins of these markers were analyzed with specific to their expression codons against these O. basilicum constituents. Our results revealed that constituents of O. basilicum have excellent binding energies against colorectal cancer genes.


Cite this article:
Balakrishnan Purushothaman, Nagarasan Suganthi , Arunachalam Jothi, Kumaran Shanmugam. Molecular Docking Studies of potential anticancer agents from Ocimum basilicum L. against human colorectal cancer regulating genes: An insilico approach. Research J. Pharm. and Tech. 2019; 12(7): 3423-3427. doi: 10.5958/0974-360X.2019.00579.1

Cite(Electronic):
Balakrishnan Purushothaman, Nagarasan Suganthi , Arunachalam Jothi, Kumaran Shanmugam. Molecular Docking Studies of potential anticancer agents from Ocimum basilicum L. against human colorectal cancer regulating genes: An insilico approach. Research J. Pharm. and Tech. 2019; 12(7): 3423-3427. doi: 10.5958/0974-360X.2019.00579.1   Available on: https://rjptonline.org/AbstractView.aspx?PID=2019-12-7-54


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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