Author(s):
S. R. Singh, K. R. Jadhav, P. K. Tripathi
Email(s):
kurmisushma@gmail.com
DOI:
10.5958/0974-360X.2019.00574.2 
Address:
S. R. Singh1*, K. R. Jadhav2, P. K. Tripathi1
1Dr. L. H. Hiranandani College of Pharmacy, Opp. Ulhasnagaar Railway Station, Ulhasnagar, Maharashtra,
India 421003
2 Bharti Vidyapeet’s College of Pharmacy, Belapur CBD, Navi Mumbai Maharashtra,
*Corresponding Author
Published In:
Volume - 12,
Issue - 7,
Year - 2019
ABSTRACT:
The objective of the present study was to develop self emulsifying drug delivery system of simvastatin to improve solubility and dissolution rate of simvastatin. Simvastatin in a BCS class II drug (poor solubility, good permeability) and low bioavailability (less than 5%). In present study simvastatin self emulsifying drug delivery system was prepared with triacetin as oil, transcutol as surfactant and propylene glycol as co-surfactant. SMEDDS was characterized for stress study, invitro drug release, globule size, zeta potential, polydispersity index, transmission electron microscopy, exvivo permeation study and pharmacodynamic study. Improvement in antihyperlipidimic potential of SMEDDS as compared to plain drug can be attributed to improvement in solubility and drug dissolution rate of simvastatin.
Cite this article:
S. R. Singh, K. R. Jadhav, P. K. Tripathi. Design and Characterization of Self Emulsifying Drug Delivery System of Simvastatin: A Technical Note. Research J. Pharm. and Tech. 2019; 12(7):3397-3404. doi: 10.5958/0974-360X.2019.00574.2
Cite(Electronic):
S. R. Singh, K. R. Jadhav, P. K. Tripathi. Design and Characterization of Self Emulsifying Drug Delivery System of Simvastatin: A Technical Note. Research J. Pharm. and Tech. 2019; 12(7):3397-3404. doi: 10.5958/0974-360X.2019.00574.2 Available on: https://rjptonline.org/AbstractView.aspx?PID=2019-12-7-49