Author(s): Raghad Alkhalil, Aya Attal, Amir Alhaj Sakur

Email(s): profsakur@gmail.com , rag.h@hotmail.com , ayaattal15@gmail.com

DOI: 10.5958/0974-360X.2019.00572.9   

Address: Raghad Alkhalil 1, Aya Attal2, Amir Alhaj Sakur3*
1,2Chemistry Department, Faculty of Sciences, University of Aleppo, Syria
3Analytical and Food Chemistry Department, Faculty of Pharmacy, University of Aleppo, Syria
*Corresponding Author

Published In:   Volume - 12,      Issue - 7,     Year - 2019


ABSTRACT:
Objective: Simple, rabid and sensitive spectrophotometric method have been developed for the determination of Amlodipine Besylate (AMD) both in pure and in pharmaceutical forms. Methods: spectrophotometric method is based on the formation of chloroform extractable blue colored ion-pair complex between Amlodipine Besylate (AMD) and Amido Black (AB)with absorption maxima at 592 nm. Results: The effects of analytical parameters on the reported system were investigated. The complexation reaction was extremely rapid at room temperature and the absorption values remain unchanged up to 24h. Various analytical parameters have been evaluated and the results have been validated by statistical. Beer’s law was obeyed in the concentration range of 1.0-56 µg.ml-1, the limit of detection was 0.16 µg.ml-1 and the molar absorptivity coefficient was1.92×104 L.moL-1.cm-1. Conclusion: The proposed method was successfully applied to the analysis of commercial dosage forms (tablets and capsules) containing the drugs with average recovery of 98.66–101.90% with RSD less than 3.84%. The method was chloroform-extractive, rapid, and have high sensitivity comparing with other previous spectrophotometric methods. Interferences of the other ingredients and excipients were not observed.


Cite this article:
Raghad Alkhalil, Aya Attal, Amir Alhaj Sakur. Spectrophotometric Determination of Amlodipine Besylate in Pure Form and Pharmaceutical Formulation using Amido Black Research J. Pharm. and Tech. 2019; 12(7):3389-3392. doi: 10.5958/0974-360X.2019.00572.9

Cite(Electronic):
Raghad Alkhalil, Aya Attal, Amir Alhaj Sakur. Spectrophotometric Determination of Amlodipine Besylate in Pure Form and Pharmaceutical Formulation using Amido Black Research J. Pharm. and Tech. 2019; 12(7):3389-3392. doi: 10.5958/0974-360X.2019.00572.9   Available on: https://rjptonline.org/AbstractView.aspx?PID=2019-12-7-47


Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags


Not Available