Bibhas Pandit, Trilochan Satapathy, Pooja Tiwari
Bibhas Pandit1*, Trilochan Satapathy1, Pooja Tiwari2
1Columbia Institute of Pharmacy, Near Vidhan Sabha, Tekari, Raipur, Chhattisgarh-493111, India.
2SLT Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Koni, Bilaspur, Chhattisgarh, India-495009.
Volume - 12,
Issue - 7,
Year - 2019
Background: Therapeutic effect of ascorbic acid on amoxicillin and clavulanic acid-induced lipid peroxidation was carried out in got liver homogenates to investigate the relationship between drug-induced toxicity and drug-induced lipid peroxidation. Methods: The level of malondialdehyde, reduced glutathione and nitric oxide were estimated in control, drug-treated, drug-antioxidant treated and the only antioxidant-treated group at two hours and six hours of incubation time. Results: The level of malondialdehyde in the drug-treated group was found to be increased whereas the level of both reduced glutathione and nitric oxide decreased when compared to control. In the drug-antioxidant treated group, the level of malondialdehyde was found to be reduced whereas the extent of reduced glutathione, nitric oxide increased when compared to the drug-treated group. Conclusion: The present study established the potential of amoxicillin and clavulanic acid to induce lipid peroxidation. On the other hand, ascorbic acid repressed lipid peroxidation to a substantial level. Lipid peroxidation initiation capability of amoxicillin and clavulanic acid might be a contributing factor for their toxicity.
Cite this article:
Bibhas Pandit, Trilochan Satapathy, Pooja Tiwari. Exploring the protective effect of Ascorbic acid on Amoxicillin and Clavulanic acid-induced lipid peroxidation in goat liver homogenate. Research J. Pharm. and Tech. 2019, 12(7):3301-3306. doi: 10.5958/0974-360X.2019.00556.0
Bibhas Pandit, Trilochan Satapathy, Pooja Tiwari. Exploring the protective effect of Ascorbic acid on Amoxicillin and Clavulanic acid-induced lipid peroxidation in goat liver homogenate. Research J. Pharm. and Tech. 2019, 12(7):3301-3306. doi: 10.5958/0974-360X.2019.00556.0 Available on: https://rjptonline.org/AbstractView.aspx?PID=2019-12-7-31