Author(s): Ajay Kumar Shukla, Ram Singh Bishnoi, Manish Kumar, C. P. Jain

Email(s): ashukla1007@gmail.com

DOI: 10.5958/0974-360X.2019.00546.8   

Address: Ajay Kumar Shukla, Ram Singh Bishnoi, Manish Kumar, C. P. Jain
Department of Pharmaceutical Sciences, Mohanlal Sukhadia University, Udaipur, Rajasthan, India
*Corresponding Author

Published In:   Volume - 12,      Issue - 7,     Year - 2019


ABSTRACT:
Objective: The objective of this work was to investigate the film coating potential of natural and modified, tamarind seed gum and fenugreek seed gum using propranolol HCl as model drug. Materials and Methods: Tamarind seed gum (TG), fenugreek seed gum (FG), sodium trimeta phosphate (STMP), propranolol HCl, hydroxypropyl methylcellulose (HPMC), sodium- alginate (SA). Core tablets of propranolol HCl were prepared and evaluated for weight, disintegration time, diameter, hardness, friability and disintegration time. The core tablets were coated using 2% w/v solution of TG, MTG, FG, MFG. The in-vitro release rate of drug from these coated tablets was compared to the release rate of drug from the tablets coated with 2% w/v of HPMC. Result: The tablets coated with natural and modified tamarind seed gum sustained the release of the drug up to 11hrs and 12hrs, respectively and natural and modified fenugreek seed gum sustained release of the drug up to 8hrs and 10 hrs respectively. The tablets coated with HPMC sustained release of the drug up to 14 hrs. The drug release profile of tablets coated with modified tamarind seed gum was comparable to the release profile of tablets coated with HPMC. Conclusion: On the basis of the release profile it is concluded that unmodified and modified TSG can be used as release rate controlling membrane.


Cite this article:
Ajay Kumar Shukla, Ram Singh Bishnoi, Manish Kumar, C. P. Jain. Development of Natural Gum Based Sustained Release Tablets of Propranolol hydrochloride. doi: 10.5958/0974-360X.2019.00546.8


Recomonded Articles:

Author(s): Sonte Sushmitha, Sedimbi Revathi Priyanka, L. Mohan Krishna, M. Srinavasa Murthy

DOI: Not Available         Access: Open Access Read More

Author(s): Katare Varsha B., Bhutkar M. A., Kumbhar A. P., Pol S. K., Katare P. B.

DOI: Not Available         Access: Open Access Read More

Author(s): Avinash Bhagwat, Suhas M Kakade, Chirag V Naval, Mukesh Tilker, Ravindra M Walture, Sagar A Adichwal and Atul P Chaudhari

DOI: Not Available         Access: Open Access Read More

Author(s): Rekha Kallam, Padma Sree K, Srinivas Arutla, MA Bari

DOI: Not Available         Access: Open Access Read More

Author(s): Barokar A.A., Wagh R.D., Baviskar D.T., Shaikh T.J.

DOI: Not Available         Access: Open Access Read More

Author(s): Deependra Jain, Nishiprakash Jain, SK Jain, Nitin Jonwal, Shashank Mishra, Deepak Bhatt, Soham Shukla

DOI: Not Available         Access: Open Access Read More

Author(s): LP Hingmire, VN Deshmukh, DM Sakarkar

DOI:         Access: Open Access Read More

Author(s): Mettu Srikanth Reddy, Mallikarjun Setty

DOI: Not Available         Access: Open Access Read More

Author(s): M.A. Saleem, Raghavendra V. Kulkurni, Patil Noornadim G

DOI: Not Available         Access: Open Access Read More

Author(s): Siddharth Kumar Sahu, Ajazuddin, Tripti Banjare, Swapnil Gupta, Akansha Bhandarkar, Hemlata Sahu, Shradha Devi Diwedi, Pankaj Sahu, Palak Agrawal, Pooja Yadav, Aditi Bhatt, Kailash Sahu, Deeksha Dewangan, HemlataThapa, Deepika, GyaneshSahu, Mukesh Sharma, D. K. Tripathi, Amit Alexander

DOI: 10.5958/0974-360X.2018.00209.3         Access: Open Access Read More

Author(s): Hitendra Choudhary, Bhagwan Yadav, Pankaj Patel, Prabhat Das, Sujit Pillai

DOI: 10.5958/0974-360X.2019.00645.0         Access: Open Access Read More

Author(s): Mahaveer Singh, Gautam Singhvi, SG Kaskhedikar, Love soni

DOI: Not Available         Access: Open Access Read More

Author(s): Dinesh S. Nandare, Satish K. Mandlik, Sachin K. Khiste, Yogesh D. Mohite

DOI: Not Available         Access: Open Access Read More

Author(s): Ujwala R. Bagmar, Dinesh C. Sancheti, Sarika R. Zade, Varsha K. Pawar, Nanda R. Badhe

DOI: Not Available         Access: Open Access Read More

Author(s): S.S. Manikiran, S.N.H. Pratap, N.L. Prasanthi, N. Ramarao

DOI: Not Available         Access: Open Access Read More

Author(s): Pankaj P. Ostwal, Yogesh L. Jadhav, Mayur S. Jain, Sumit P. Jain

DOI: Not Available         Access: Open Access Read More

Author(s): Deepali Avinash Meher

DOI: Not Available         Access: Open Access Read More

Author(s): Suman Katteboina and VSR Chandrasekhar P

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags