Research Journal of Pharmacy and Technology

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0974-360X (Online)
0974-3618 (Print)


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Development of Natural Gum Based Sustained Release Tablets of Propranolol hydrochloride

Author(s): Ajay Kumar Shukla, Ram Singh Bishnoi, Manish Kumar, C. P. Jain

Email(s): ashukla1007@gmail.com

DOI: 10.5958/0974-360X.2019.00546.8   

Address: Ajay Kumar Shukla, Ram Singh Bishnoi, Manish Kumar, C. P. Jain
Department of Pharmaceutical Sciences, Mohanlal Sukhadia University, Udaipur, Rajasthan, India
*Corresponding Author

Published In:   Volume - 12,      Issue - 7,     Year - 2019

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ABSTRACT:
Objective: The objective of this work was to investigate the film coating potential of natural and modified, tamarind seed gum and fenugreek seed gum using propranolol HCl as model drug. Materials and Methods: Tamarind seed gum (TG), fenugreek seed gum (FG), sodium trimeta phosphate (STMP), propranolol HCl, hydroxypropyl methylcellulose (HPMC), sodium- alginate (SA). Core tablets of propranolol HCl were prepared and evaluated for weight, disintegration time, diameter, hardness, friability and disintegration time. The core tablets were coated using 2% w/v solution of TG, MTG, FG, MFG. The in-vitro release rate of drug from these coated tablets was compared to the release rate of drug from the tablets coated with 2% w/v of HPMC. Result: The tablets coated with natural and modified tamarind seed gum sustained the release of the drug up to 11hrs and 12hrs, respectively and natural and modified fenugreek seed gum sustained release of the drug up to 8hrs and 10 hrs respectively. The tablets coated with HPMC sustained release of the drug up to 14 hrs. The drug release profile of tablets coated with modified tamarind seed gum was comparable to the release profile of tablets coated with HPMC. Conclusion: On the basis of the release profile it is concluded that unmodified and modified TSG can be used as release rate controlling membrane.


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Cite this article:
Ajay Kumar Shukla, Ram Singh Bishnoi, Manish Kumar, C. P. Jain. Development of Natural Gum Based Sustained Release Tablets of Propranolol hydrochloride. doi: 10.5958/0974-360X.2019.00546.8


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Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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