Author(s):
Jennifer Fernandes, Ronald Fernandes, Vijay Kumar M., Rajisha K., Ryna V. Lobo
Email(s):
ronaldfernandes@nitte.edu.in
DOI:
10.5958/0974-360X.2019.00551.1 
Address:
Jennifer Fernandes, Ronald Fernandes*, Vijay Kumar M., Rajisha K., Ryna V. Lobo
Department of Pharmaceutical Chemistry, N.G.S.M. Institute of Pharmaceutical Sciences,
NITTE (Deemed to be University), Paneer, Deralakatte, Mangalore-575018
*Corresponding Author
Published In:
Volume - 12,
Issue - 7,
Year - 2019
ABSTRACT:
Diabetes mellitus is a metabolic disorder which results from defects in insulin secretion. Among the various methods of diabetes management, herbal products are best alternative drug with zero side-effects. The aim of this work was to assess the phytochemicals qualitatively and to evaluate the anti-diabetic activity of unripe fruits extract of Artocarpus gomezianus. The in vitro alpha-amylase and alpha-glucosidase inhibitory studies were performed using different concentration of extract and compared with a standard drug. Our assay result suggests that methanolic extract of Artocarpus gomezianus exhibit dose-dependent increase in percentage inhibitory activity on a-glucosidase enzymes (IC50 is 70.29) and a-amylase (IC50 is 68.75). Acarbose was used as a standard drug.
Cite this article:
Jennifer Fernandes, Ronald Fernandes, Vijay Kumar M., Rajisha K., Ryna V. Lobo. In vitro Antihyperglycemic activity of unripe fruits extracts of Artocarpus gomezianus. Research J. Pharm. and Tech. 2019; 12(7):3265-3267. doi: 10.5958/0974-360X.2019.00551.1
Cite(Electronic):
Jennifer Fernandes, Ronald Fernandes, Vijay Kumar M., Rajisha K., Ryna V. Lobo. In vitro Antihyperglycemic activity of unripe fruits extracts of Artocarpus gomezianus. Research J. Pharm. and Tech. 2019; 12(7):3265-3267. doi: 10.5958/0974-360X.2019.00551.1 Available on: https://rjptonline.org/AbstractView.aspx?PID=2019-12-7-24