ABSTRACT:
The present report describes the synthesis of heterocyclic compounds on creatinine ring, the synthetic route started from reaction creatinine with chloroacetyl chloride to give compound (1a). Compound (1a) react with urea/thiourea respectively to give compounds (2a-3a),Shiff bases were synthesized by the reaction compounds (2a-3a) with benzaldehyde andm- nitrobenzaldehyde, respectively to give compounds (4a-5a). Esterification of compounds (4a-5a) with a- chloroethylacetate to give compounds (6a-7a). Esters derivatives were synthesized by the reaction compounds (6a-7a) with semithiocarbazide respectivelyto give compounds (8a-9a). The compounds (8a-9a) reacts with NaOH to give compounds (10a-11a). The synthesized compounds characterized by FT-IR and1HNMR spectroscopy. Beside the experimental work, we worked theoretical study involving calculated the energies. Also this study was designed to show the effects of creatinine derivatives on the activities of some transferase enzymes such as: SGOT, and SGPT enzymes in sera.