Author(s): Mukthinuthalapati Mathrusri Annapurna, Rajani Kaibada, Mandula Srinivas

Email(s): mannapurna.mukthinuthalapati@gitam.edu

DOI: 10.5958/0974-360X.2019.00444.X   

Address: Mukthinuthalapati Mathrusri Annapurna*, Rajani Kaibada, Mandula Srinivas
Department of Pharmaceutical Analysis and Quality Assurance GITAM Institute of Pharmacy,
GITAM (Deemed to be University), Visakhapatnam, Andhra pradesh-530045
*Corresponding Author

Published In:   Volume - 12,      Issue - 6,     Year - 2019


ABSTRACT:
A new RP-UFLC method has been developed and validated for the determination of Perampanel in its capsules using Shimadzu Model CBM-20A/20 Alite UFLC system (Shimadzu Co., Kyoto, Japan) equipped with SPD M20A prominence photodiode array detector on C8 (2) 100A (Luna) column (250 mm×4.60 mm i.d. 5µm particle size)maintained at room temperature. Mobile phase consisting of a mixture of water, acetonitrile and 0.1% acetic acid (50:50:0.1 v/v) was chosen with a flow rate of 1 mL/min (UV detection at 215nm) on isocratic mode. Perampanel obeys Beer-Lambert’s law over the concentration range 0.05–120 µg/mL with linear regression equation y=73084x+13800 (r2=0.9999). Forced degradation studies were performed and the method was validated as per ICH guidelines.


Cite this article:
Mukthinuthalapati Mathrusri Annapurna, Rajani Kaibada, Mandula Srinivas. New Stability Indicating RP-Ultra Fast Liquid Chromatographic Method for the Determination of Perampanel–An Antiepileptic Drug. Research J. Pharm. and Tech. 2019; 12(6): 2657-2663. doi: 10.5958/0974-360X.2019.00444.X

Cite(Electronic):
Mukthinuthalapati Mathrusri Annapurna, Rajani Kaibada, Mandula Srinivas. New Stability Indicating RP-Ultra Fast Liquid Chromatographic Method for the Determination of Perampanel–An Antiepileptic Drug. Research J. Pharm. and Tech. 2019; 12(6): 2657-2663. doi: 10.5958/0974-360X.2019.00444.X   Available on: https://rjptonline.org/AbstractView.aspx?PID=2019-12-6-7


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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