Author(s): Sengamalam Radhakrishnan, S. Meena, Ravindran Muthukumarasamy

Email(s): Email ID Not Available

DOI: 10.5958/0974-360X.2019.00484.0   

Address: Sengamalam Radhakrishnan1, Dr. S. Meena2, Ravindran Muthukumarasamy3*
1E.G.S. Pillay College of Pharmacy, Nagapattinam, Tamilnadu, India.
2College of Pharmacy, Shaqra University, Dawadmi, Kingdom of Saudi Arabia.
3Universiti Kuala Lumpur, Royal College of Medicine Perak, Faculty of Pharmacy and Health Sciences, Ipoh, Perak, Malaysia.
*Corresponding Author

Published In:   Volume - 12,      Issue - 6,     Year - 2019


ABSTRACT:
Duloxetine is chemically N – methyl-3-(1-naphthyloxy)-3-(thiophen-2-yl)-propan-1-amine, is a balanced and potent reuptake inhibitor of serotonin and norepinephrine. Methylcobalamin is chemically Methyl-5, 6-dimethyl benzimidazolylcobalamin, is one of the two coenzyme forms of vitamin B12 in the enzyme methionine synthase which functions to transfer methyl groups for the regeneration of methionine from homocysteine. The combination of these two drugs is used in relieving the complications of diabetic peripheral neuropathy. The aim of the current study is to develop a modified simultaneous spectrophotometric determination (Q-Absorbance ratio method) of duloxetine and methylcobalaminin bulk and pharmaceutical dosage form (tablet and capsule). Duloxetine has exhibited maximum absorbance at 288 nm and it transparent at 326 nm. The isobestic point was selected at 254 nm as both the drugs recorded maximum absorbance, also it was found wavelength difference is higher when compared to 278 nm. In replicate analysis (n=5) of the two drugs by the proposed UV method, the % label claim and % RSD of duloxetine and methylcobalamin were appreciably low for tablet and capsule formulation. The correlation between absorbance and concentration in terms of correlation coefficient (r) was found to be 0.9956 and 0.9979. The validation parameters observed proved that this method simple, sensitive, accurate and precise. Hence, the developed new method can be employed for the routine analysis of these two drugs in combined dosage forms.


Cite this article:
Sengamalam Radhakrishnan, S. Meena, Ravindran Muthukumarasamy. Modified Simultaneous Spectrophotometric Method Development for the Estimation of Duloxetine and Methylcobalamin in Bulk, Tablet and Capsule Dosage Forms. Research J. Pharm. and Tech. 2019; 12(6): 2877 – 2880. doi: 10.5958/0974-360X.2019.00484.0

Cite(Electronic):
Sengamalam Radhakrishnan, S. Meena, Ravindran Muthukumarasamy. Modified Simultaneous Spectrophotometric Method Development for the Estimation of Duloxetine and Methylcobalamin in Bulk, Tablet and Capsule Dosage Forms. Research J. Pharm. and Tech. 2019; 12(6): 2877 – 2880. doi: 10.5958/0974-360X.2019.00484.0   Available on: https://rjptonline.org/AbstractView.aspx?PID=2019-12-6-47


Recomonded Articles:

Author(s): Ravindranath S. Misal, Vishawas R. Potphode, Vijay R. Mahajan

DOI: 10.5958/0974-360X.2017.00218.9         Access: Open Access Read More

Author(s): Niharika, Navneet Verma

DOI: 10.5958/0974-360X.2016.00182.7         Access: Open Access Read More

Author(s): Peethala Prathyusha, Raja Sundararajan, Palyam Bhanu, Mathrusri Annapurna Mukthinuthalapati

DOI: 10.5958/0974-360X.2020.00507.7         Access: Open Access Read More

Author(s): Vijayalakshmi. S , Disalva. X, Chittaranjan Srivastava, Arun A

DOI: 10.5958/0974-360X.2019.00520.1         Access: Open Access Read More

Author(s): Dhara Parekh, Pankaj Kapupara, Ketan Shah

DOI: dharaparekh92@gmail.com         Access: Open Access Read More

Author(s): R Deveswaran, S Bharath, BV Basavaraj, Sindhu Abraham, Sharon Furtado, V Madhavan

DOI:         Access: Open Access Read More

Author(s): Suha Alnaeb, Youssef Alahmad, Saleh Trefi

DOI: 10.5958/0974-360X.2019.01035.7         Access: Open Access Read More

Author(s): R. P. Bhole, S. R. Jagtap, K. B. Chadar, Y. B. Zambare

DOI: 10.5958/0974-360X.2020.00189.4         Access: Open Access Read More

Author(s): Yarnykh T. G., Kotvitska A. A., Tykhonov A. I., Rukhmakova O. A.

DOI: 10.5958/0974-360X.2020.00614.9         Access: Open Access Read More

Author(s): Bahubali N. Patil, Vamshi Krishna Tippavajhala, Girish Pai K

DOI: 10.5958/0974-360X.2019.00140.9         Access: Open Access Read More

Author(s): U.S Mahadeva Rao, Khamsah Suryati Mohd, Abdurrazaq Muhammad, Bashir Ado Ahmad, Mohaslinda Mohamad, Rosmawati Mat Ali

DOI: Not Available         Access: Open Access Read More

Author(s): Narendra Chotai, Vishnu Patel, Harsha Patel, Uren Patel, Rajendra Kotadiya

DOI:         Access: Open Access Read More

Author(s): Prabhakar Panzade, Prashant K Puranik

DOI: Not Available         Access: Open Access Read More

Author(s): Mythili. L, GNK. Ganesh, C. Monisha, Kayalvizhi. R

DOI: 10.5958/0974-360X.2019.00426.8         Access: Open Access Read More

Author(s): Suchithra. A. B, S. Jeganath, E. Jeevitha

DOI: 10.5958/0974-360X.2019.01073.4         Access: Open Access Read More

Author(s): Vijaykumar T. Pawar, Shubhangi V. Pawar, Harinath N. More, Anita S. Kulkarni, Dinanath T. Gaikwad

DOI: 10.5958/0974-360X.2017.00724.7         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags