Author(s): Muhamad Esam Kaf Alghazal, Fadi Alrouh, Yaser Bitar, Saleh Trefi

Email(s): salehtrefi@yahoo.com

DOI: 10.5958/0974-360X.2019.00480.3   

Address: Muhamad Esam Kaf Alghazal1, Fadi Alrouh2, Yaser Bitar1, Saleh Trefi1
1Pharmaceutical Quality and Pharmaceutical Chemistry Department-Faculty of Pharmacy –University of Aleppo-Syria
2Organic Chemistry Department–Faculty of Medicine- University of Al-Hawash –Syria
*Corresponding Author

Published In:   Volume - 12,      Issue - 6,     Year - 2019


ABSTRACT:
A specific and highly sensitive gas chromatographic method was developed for the simultaneous determination of chlorpheniramine maleate and dimenhydrinate using one drug as internal standard for the other one. The chromatographic conditions are aTRB-5-625 capillary column (60m × 0.25 mm i.d0.25µm film thickness) and nitrogen as a carrier gas at a flow rate of 1.0 mL min. The oven temperature was programmed at 230°C for 1 min, with a rise of 20°C min up to 250°C (held for 7 min). The injector and detector port temperatures were maintained at 290°C. Detection was carried out using flame ionization detector. Results of assay and recovery studies were statistically evaluated for its accuracy and precision using one drug as internal stander for the other one and vice versa. Objective: The objective of this study was to develop and validate a gas chromatographic method to separate and assay to antihistamine drugs, dimenhydrinate and chlorpheniramine maleate in pharmaceutical forms. This method was a practical additional choice in quality control laboratories.


Cite this article:
Muhamad Esam Kaf Alghazal, Fadi Alrouh, Yaser Bitar, Saleh Trefi. Determination of Dimenhydrinate and Chlorpheniramine Maleate in Pharmaceutical Forms by new Gas Chromatography Method. Research J. Pharm. and Tech. 2019; 12(6): 2851 -2856. doi: 10.5958/0974-360X.2019.00480.3

Cite(Electronic):
Muhamad Esam Kaf Alghazal, Fadi Alrouh, Yaser Bitar, Saleh Trefi. Determination of Dimenhydrinate and Chlorpheniramine Maleate in Pharmaceutical Forms by new Gas Chromatography Method. Research J. Pharm. and Tech. 2019; 12(6): 2851 -2856. doi: 10.5958/0974-360X.2019.00480.3   Available on: https://rjptonline.org/AbstractView.aspx?PID=2019-12-6-43


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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