Author(s): Sowjanya. K, R. Ratna Manjula, Vaishnavi. V, B. Keerthi Sai, Divya. K

Email(s): ksowjanya.1504@gmail.com

DOI: 10.5958/0974-360X.2019.00453.0   

Address: Sowjanya. K1, R. Ratna Manjula2, Vaishnavi. V3, B. Keerthi Sai4, Divya. K5
1Associate Professor, Department of Pharmaceutical Chemistry, Nirmala College of Pharmacy, Atmakur (V), Guntur, Andhra Pradesh, India-522503
2Associate Professor, Department of Pharmaceutical and Phytochemistry, Nirmala College of Pharmacy, Atmakur (V), Guntur, Andhra Pradesh, India-522503
3,4,5Bachelor of Pharmacy, Nirmala College of Pharmacy, Atmakur (V), Guntur, Andhra Pradesh, India-522503.
*Corresponding Author

Published In:   Volume - 12,      Issue - 6,     Year - 2019


ABSTRACT:
Objective: Hibiscus plantifolius is a shrub with various medicinal uses and belongs to the Malvaceae family. The present study is aimed at determining in vivo antioxidant activity of MEHP using the paracetamol-induced hepatotoxicity test in rats. Methods: The animals were randomly divided into 7 experimental groups and administered with test solutions. Rats were divided into seven groups and received 10% DMSO (negative control), Paracetamol (2 gm/kg bd. wt.), Silymarin (10 mg/kg bd.wt.) or 50mg/kg MEHP (50, 150 and 300 mg/kg) orally once daily for 7 consecutive days. The oral administration of paracetamol was performed 3 hours after the last extract administration on the 7th day. The blood and liver tissues were collected and subjected to biochemical and microscopical analysis. Results: In this study, it was observed that MEHP extract significantly (p<0.05) increased hepatic SOD and CAT activities in paracetamol-induced liver damage in rats. The antioxidant activity was exhibited due to presence of flavonoids and tannins, phenolic compounds which was present methanolic extract of Hibiscus plantifolius. Conclusion: The antioxidant activity was exhibited due to presence of flavonoids and tannins, phenolic compounds which was present methanolic extract of Hibiscus plantifolius.


Cite this article:
Sowjanya. K, R. Ratna Manjula, Vaishnavi. V, B. Keerthi Sai, Divya. K. In-Vivo Antioxidant Activity of Hibiscus plantifolius Stems. Research J. Pharm. and Tech. 2019; 12(6): 2712-2715. doi: 10.5958/0974-360X.2019.00453.0


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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