Author(s): Vinod Kumari, Aditi Sangal

Email(s): dahiyavinod123@gmail.com

DOI: 10.5958/0974-360X.2019.00253.1   

Address: Vinod Kumari*, Aditi Sangal
Department of Chemistry, Amity Institute of Applied Sciences, Amity University, Sector 125, Noida, Uttar Pradesh-201313 (India)
*Corresponding Author

Published In:   Volume - 12,      Issue - 4,     Year - 2019


ABSTRACT:
Nanoscale drug delivery systems have shown their ability to encapsulate a variety of therapeutic agents. By encapsulating these molecules the solubility and stability of drug is improved. Cinnamon act as potential drug for lot of curable diseases such as Diabetes. For increasing its bioavailability as a drug, nanoencapsulation of cinnamon powder was carried out using solvent evaporation method. The effect of organic solvent and surfactant such as PVA (Polyvinyl alcohol) and Pluronic F-68 was studied. The morphology and particle size of nanoparticles was studied using Transmission Electron Microscopy (TEM) which shows nanoparticles of small size (10 nm for Cinnamon. Nanoencapsulation of Cinnamon also shows high entrapment efficiency (82.34% for Cinnamon) respectively and also improvement in inhibition of microbial growth. During microbial analysis, the minimum inhibitory concentration (MIC) of Cinnamon loaded nanoparticles against the Staphylococcus aureus and Bacillus pumilus shows the inhibition zone of 9.12 mm and 10.39mm respectively at 6000 ppm whereas in case of Saccharomyces cerevisiae and Candida albicans the nanopaticles shows inhibition zone of 7.23mm and 8.47 mm respectively at 4000ppm. Drug release study for cinnamon and corresponding nanoparticles was also done. The main objective behind the work in hand is the preparation of Cinnamon loaded poly (lactic-co-glycolic acid) (PLGA) nanoparticles for increasing the efficacy towards different ailments.


Cite this article:
Vinod Kumari, Aditi Sangal. Synthesis, Characterization, Antimicrobial activity and Release Study of Cinnamon loaded poly (DL-lactide-co-glycolide) Nanoparticles. Research J. Pharm. and Tech. 2019; 12(4):1529-1535. doi: 10.5958/0974-360X.2019.00253.1


Recomonded Articles:

Author(s): Nimbalkar V.V., Pansare P.M., Nishane B.B.

DOI: 10.5958/0974-360X.2015.00310.8         Access: Open Access Read More

Author(s): Ravindranath S. Misal, Vishawas R. Potphode, Vijay R. Mahajan

DOI: 10.5958/0974-360X.2017.00218.9         Access: Open Access Read More

Author(s): Niharika, Navneet Verma

DOI: 10.5958/0974-360X.2016.00182.7         Access: Open Access Read More

Author(s): Rakhi Mehra, Renu Makhija, Neera Vyas

DOI: Not Available         Access: Open Access Read More

Author(s): A. S. K. Sankar, B. Datchayani, N. Balakumaran, Mohammed Rilwan, R. Subaranjani

DOI: 10.5958/0974-360X.2017.00047.6         Access: Open Access Read More

Author(s): Jino Elsa Thomas, Usha Y Nayak*, Jagadish PC, Koteshwara KB

DOI: 10.5958/0974-360X.2017.00007.5         Access: Open Access Read More

Author(s): R. Narayana Charyulu, P. Parvathy Devi, Jobin Jose, A. Veena Shetty

DOI: Not Available         Access: Open Access Read More

Author(s): Sonte Sushmitha, Sedimbi Revathi Priyanka, L. Mohan Krishna, M. Srinavasa Murthy

DOI: Not Available         Access: Open Access Read More

Author(s): Raj Kumar R, Praveen D, Palani Shanmugasundaram

DOI: 10.5958/0974-360X.2016.00164.5         Access: Open Access Read More

Author(s): V. Padmaharish

DOI: 10.5958/0974-360X.2016.00190.6         Access: Closed Access Read More

Author(s): Priya P. Munshi, D.S. Mohale, R. Akkalwar, A.V. Chandewar

DOI: Not Available         Access: Open Access Read More

Author(s): Deepak Karki, Gururaj S. Kulkarni, Shivakumar Swamy, Sheeba FR

DOI: 10.5958/0974-360X.2017.00750.8         Access: Open Access Read More

Author(s): Mistry Khushboo, Kavya Naik, Vasanthi, Alicia Menezes, Anup Naha, K.B. Koteshwara, K. Girish Pai

DOI: 10.5958/0974-360X.2017.00540.6         Access: Open Access Read More

Author(s): Leelavathi D Acharya, N R Rau, N Udupa, Surulivel Rajan M, Vijayanarayana K

DOI: 10.5958/0974-360X.2016.00162.1         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags