ABSTRACT:
Objective: Aim of present work is to formulate and evaluate fast dissolving tablets of Aripiprazole. Experimental work: Initially complexes of drug were made with ß- cyclodextrin in the molar ratio of 1:1 to 1:4 by kneading method to mask the bitter taste of drug and fast dissolving tablets were prepared by direct compression method using 32 factorial design. Evaluation of taste masking was done by Electronic Tongue. The optimized batch was subjected for short term stability study at 40ºC with RH of 75% for a period one month. Drug release mechanism was determined by fitting drug release data of S5 to various kinetic models. Result and Discussion: Drug ß- cyclodextrin complex in the ratio of 1:4 efficiently masked the bitter taste of drug. Fast dissolving tablets were evaluated for their post compression properties. The optimized batch S5 released the drug upto 98.8 within 30 min. By comparing the correlation coefficient values from the applied models, the Koresmayer Peppas was shown the most appropriate to describe the kinetics of S5 formulation. Conclusion: Complexes of drug were made with ß-cyclodextrin in the molar ratio of 1:1 to 1:4 by kneading method. Among all the formulation, it was conclude that S5 optimized batch which shows the higher drug release up to 98.8 % and disintegration time 18 sec so, S5 is the best optimized batch. Drug release mechanisms were determined by fitting drug release data of S5 to various kinetic models. By comparing the correlation coefficient values from the applied models, the Koresmayer peppas was shown the most appropriate to describe the kinetics of S5 formulation.