Author(s): Abdul Kareem Hamad Ayfan, Rasim Farraj Muslim, Noor Sabah Noori

Email(s): kareemhamad7@gmail.com , dr.rasim92hmts@gmail.com , noorahmed1988@yahoo.com

DOI: 10.5958/0974-360X.2019.00167.7   

Address: Abdul Kareem Hamad Ayfan1, Rasim Farraj Muslim2*, Noor Sabah Noori3
1Pharmacy College, University Of Anbar, Anbar, Iraq
2Department of Ecology, College of Applied Sciences-Hit, University Of Anbar, Anbar, Iraq
3Department of Chemistry, College of Science, University Of Anbar, Anbar, Iraq
*Corresponding Author

Published In:   Volume - 12,      Issue - 3,     Year - 2019


ABSTRACT:
This research includes synthesis of new heterocyclic derivatives of novel disubstituted 1,3- oxazepine-tetra-one from Schiff bases reaction with 3-methylfuran-2,5-dione and 3-phenyldihydrofuran-2,5-dione. Schiff bases [A1-A5] were synthesized by the reaction of aromatic aldehydes with primary aromatic amines, in the presence of glacial acetic acid as catalyst in absolute ethanol. The novel derivatives[A6-A10] were obtained from treatment of Schiff bases with anhydrides. The synthesized compounds were identified by TLC and via spectral methods, their (FT-IR, 1H-NMR and 13C-NMR) and measurements of some of its physical properties.


Cite this article:
Abdul Kareem Hamad Ayfan, Rasim Farraj Muslim, Noor Sabah Noori. Preparation and Characterization of Novel disubstituted 1,3- Oxazepine-tetra-one from Schiff bases reaction with 3-methylfuran-2,5-dione and 3-Phenyldihydrofuran-2,5-dione. Research J. Pharm. and Tech. 2019; 12(3): 1008-1016. doi: 10.5958/0974-360X.2019.00167.7

Cite(Electronic):
Abdul Kareem Hamad Ayfan, Rasim Farraj Muslim, Noor Sabah Noori. Preparation and Characterization of Novel disubstituted 1,3- Oxazepine-tetra-one from Schiff bases reaction with 3-methylfuran-2,5-dione and 3-Phenyldihydrofuran-2,5-dione. Research J. Pharm. and Tech. 2019; 12(3): 1008-1016. doi: 10.5958/0974-360X.2019.00167.7   Available on: https://rjptonline.org/AbstractView.aspx?PID=2019-12-3-6


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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