Author(s): Debi Prasad Pradhan, Mukthinuthalapati Mathrusri Annapurna

Email(s): debi.rips@gmail.com

DOI: 10.5958/0974-360X.2019.00128.8   

Address: Debi Prasad Pradhan*, Mukthinuthalapati Mathrusri Annapurna
Department of Pharmaceutical Analysis & Quality Assurance, GITAM Institute of Pharmacy,
GITAM (Deemed to be University), Visakhapatnam, Andhra pradesh-530045, India.
*Corresponding Author

Published In:   Volume - 12,      Issue - 2,     Year - 2019


ABSTRACT:
Oxcarbazepine is an anticonvulsant drug used for the treatment of epilepsy. It acts by decreasing the abnormal electrical activity in the brain. A new stability indicating HPLC method was developed for the quantification of Oxcarbazepine in tablets. Waters e2695 Separations module with Waters 2489 UV detector with Hypersil BDS C18 column (250 mm x 4.6 mm, 5µ) was operated with column temperature 50°C. The detector was monitored at 215 nm and the chromatographic study was run for 20 min. Linearity was observed over 5.0-150 µg/mL with linear regression equation y = 47,910x + 6493.8 with correlation coefficient R² = 0.9999. The LOQ and LOD were found to be 4.5129 µg/mL and 1.4898 µg/mL respectively. Forced degradation studies were performed for Oxcarbazepine capsules and the method was validated as per ICH guidelines.


Cite this article:
Debi Prasad Pradhan, Mukthinuthalapati Mathrusri Annapurna .Stability indicating HPLC-DAD method for the determination of Oxcarbazepine - An Anticonvulsant. Research J. Pharm. and Tech 2019; 12(2):723-728. doi: 10.5958/0974-360X.2019.00128.8

Cite(Electronic):
Debi Prasad Pradhan, Mukthinuthalapati Mathrusri Annapurna .Stability indicating HPLC-DAD method for the determination of Oxcarbazepine - An Anticonvulsant. Research J. Pharm. and Tech 2019; 12(2):723-728. doi: 10.5958/0974-360X.2019.00128.8   Available on: https://rjptonline.org/AbstractView.aspx?PID=2019-12-2-47


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DOI: 10.5958/0974-360X 

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