Author(s): Ragini V. Mane, Kritika Patel, Gude Sai Sushmitha, S G Vasantharaju

Email(s): sgvasanth65@gmail.com

DOI: 10.5958/0974-360X.2019.00108.2   

Address: Ragini V. Mane, Kritika Patel, Gude Sai Sushmitha, Dr. S G Vasantharaju*
Dept. of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences,
Manipal Academy of Higher Education, Manipal-576104, Karnataka, India
*Corresponding Author

Published In:   Volume - 12,      Issue - 2,     Year - 2019


ABSTRACT:
An effective and simple UV-Spectrophotometric method was developed and validated for the quantification of Diclofenac sodium in tablets. The maximum absorption was found to be 282nm by using methanol as the solvent. The linearity range was 6-21 µg/ml and the correlation coefficient (r²) was found to be 0.9985. The method was accurate, precise, and robust with %RSD below 2%. The LOD and LOQ was found to be 0.0885µg/Ml and 0.250µg/mL respectively. Sandel’s sensitivity was found to be 0.000002 µg/mL. Assay and accuracy of the tablets were about of the acceptance criteria range as per the ICH guidelines.


Cite this article:
Ragini V. Mane, Kritika Patel, Gude Sai Sushmitha, S G Vasantharaju. Development and Validation of Diclofenac sodium in tablets using Simple UV Spectrophotometric method. Research J. Pharm. and Tech 2019; 12(2):611-614. doi: 10.5958/0974-360X.2019.00108.2

Cite(Electronic):
Ragini V. Mane, Kritika Patel, Gude Sai Sushmitha, S G Vasantharaju. Development and Validation of Diclofenac sodium in tablets using Simple UV Spectrophotometric method. Research J. Pharm. and Tech 2019; 12(2):611-614. doi: 10.5958/0974-360X.2019.00108.2   Available on: https://rjptonline.org/AbstractView.aspx?PID=2019-12-2-27


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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