Author(s): Divya, Prasanna Shama Khandige, Ullas Prakash D’ Souza, Himanshu Joshi, Zeena Fernandes, Gururaj M. P, Nimmy Chackko, Shastry C. S.

Email(s): prasannasham@nitte.edu.in

DOI: 10.5958/0974-360X.2019.01042.4   

Address: Divya, Prasanna Shama Khandige*, Ullas Prakash D’ Souza, Himanshu Joshi, Zeena Fernandes, Gururaj M. P, Nimmy Chackko, Shastry C. S.
NGSM Institute of Pharmaceutical Sciences, A Constituent College of Nitte Deemed-to-be University Paneer, Deralakatte, Mangalore, Karnataka India 575018
*Corresponding Author

Published In:   Volume - 12,      Issue - 12,     Year - 2019


ABSTRACT:
In the present study an attempt were made to evaluate and prove the Anti-Epileptic activity of Carica papaya. Seed extract in experimental animals. The papaya seed was collected from local garden of deralaktte D.K district. it was subjected for shade drying and size reduced to powders and extracted by maceration technique with ethanol. Preliminary phytochemical studies qualitative analysis to test the chemical constituents and acute toxicity studied were carried to determine a sage dosage regimen for testing the extract as per OECD guideline and Limit 2000mg/kg/b.w in experimental animals, a three dosage regimen were selected All the animals were subjected to a dosage regimen with their respective drug for a time period of 14 days. Maximal electro shock (MES) method, Pentylenetetrazole (PTZ) induced seizure were performed to evaluate e the antiepileptic activity. Reduction in the extensor phase and no of convulsions were tabulated. Dose dependent and significant (p<0.01) anti-epileptic activity in in-vivo study were obtained. Seed extract at a dose of 400mg/kg revealed better activity compared to 100 and 200mg/kg body weight and control group. The result showed a promising antiepileptic potential of the papaya seed. However further pharmacological investigation using isolated active ingredients can be carried out to confirm the efficacy and mechanism of action.


Cite this article:
Divya, Prasanna Shama Khandige, Ullas Prakash D’ Souza, Himanshu Joshi, Zeena Fernandes, Gururaj M. P, Nimmy Chackko, Shastry C. S.. Anti-epileptic Activity of Carica papaya seed extract in Experimental Animals. Research J. Pharm. and Tech. 2019; 12(12): 6007-6012. doi: 10.5958/0974-360X.2019.01042.4


Recomonded Articles:

Author(s): Koushika Das, Pranit Krishna, Avipsha Sarkar, Shanmuga Sundari Ilangovan, Shampa Sen

DOI: 10.5958/0974-360X.2017.00267.0         Access: Open Access Read More

Author(s): U.S Mahadeva Rao, Khamsah Suryati Mohd, Abdurrazaq Muhammad, Bashir Ado Ahmad, Mohaslinda Mohamad, Rosmawati Mat Ali

DOI: Not Available         Access: Open Access Read More

Author(s): A. Julius, Ramachandran Vedasendiyar, Archana Devakannan, Sujatha Rajaraman, Balamurugan Rangasamy, V. Saravanan

DOI: 10.5958/0974-360X.2017.00062.2         Access: Open Access Read More

Author(s): Avinash Bhagwat, Suhas M Kakade, Chirag V Naval, Mukesh Tilker, Ravindra M Walture, Sagar A Adichwal and Atul P Chaudhari

DOI: Not Available         Access: Open Access Read More

Author(s): Kousalya M., Geetha P., Jesuraja A., Vinoth Kumar M

DOI: 10.5958/0974-360X.2017.00014.2         Access: Open Access Read More

Author(s): Niha Naveed, Karthikeyan Murthykumar, Subasree Soundarajan, Sripradha Srinivasan

DOI: Not Available         Access: Open Access Read More

Author(s): Pankaj Kumar, Jennifer Fernandes, Abhishek Kumar

DOI: 10.5958/0974-360X.2017.00023.3         Access: Open Access Read More

Author(s): Mohammed Ehtesham Ur Rahman, Mohammed Abdul Haseeb, Mohammed Saleem, Abdul Naveed

DOI: Not Available         Access: Open Access Read More

Author(s): Tarasankar Maity, Ayaz Ahmad, Nilanjan Pahari, Subarna Ganguli

DOI: Not Available         Access: Open Access Read More

Author(s): Uday Gaikwad, Milind Parle

DOI: Not Available         Access: Open Access Read More

Author(s): Das Biswajit, Dash Suvakanta, Choudhury Ramesh Chandra

DOI: Not Available         Access: Open Access Read More

Author(s): Jyothi.S, Karthikeyan Murthykumar, Anupama Deepak, Dhanraj, Noorul Aneesa, Sowndarya Baskar, Lakshya Rani

DOI: 10.5958/0974-360X.2016.00113.X         Access: Open Access Read More

Author(s): Neha Rajput, Dinesh Sachan, Shikha Gangwar, Dipti Sachan

DOI: Not Available         Access: Open Access Read More

Author(s): Shrivastava Alankar, Jain R., Agrawal R.K., Ahirwar D.

DOI:         Access: Open Access Read More

Author(s): Pavani M., D.P. Mastan Yadav, Manikanta Kumar A., K.S. Manjunath Shetty

DOI: Not Available         Access: Open Access Read More

Author(s): Saba Shaikh, Ravi Dubey, Swati Dhande, Y.M Joshi, Vilasrao J. Kadam

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags