ABSTRACT:
This article describes an effective method of modified maceration to obtain of the extract of Frangula alnus, which can later be used for various dosage forms. The study used four methods for extracting: method of modified maceration, method of maceration, method of percolation, method of repercolation. When using the modified maceration method, the maximum yield of anthracene derivatives from the medicinal plant materials was observed. The method of obtaining of medicinal product in the form of Frangula alnus bark extract, obtained by water-alcohol extraction is characterized in that water-alcohol extraction of Frangula alnus bark is done by dividing the raw material into 3 equal parts, 40% ethyl alcohol is added to each part at a ratio of "raw materials - extractant" 1:10, and then the first part insist for 48 hours, the second - 12 hours, the third - 30 minutes in a boiling water bath; then the raw material is squeezed out, the extraction is settled for 2 days in the cold (at a temperature of 8 º?) for precipitate the ballast substances, then it is filtered out. The obtained water-alcohol extraction of Frangula alnus bark is brittle evaporated to a thick extract with a moisture content of not more than 25% (registration number of the patent application ?2019106226).