Author(s): Ayad Kareem Khan, Mohamed Dhiaa Hamdee

Email(s): ayad@uomustansiriyah.edu.iq

DOI: 10.5958/0974-360X.2019.01014.X   

Address: Ayad Kareem Khan, Mohamed Dhiaa Hamdee
Department of Pharmaceutical Chemistry, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq.
*Corresponding Author

Published In:   Volume - 12,      Issue - 12,     Year - 2019


ABSTRACT:
A new series of hydrochlorothiazide derivatives linked to heterogeneous rings such as 1,3,4-thiadiazine [3], 3,5-dihydroxypyrazolidin [4], 6-hydroxy-2-thioxo-1,3,4-thiadiazinane [5] and diazenyl-5-methyl-2,4-dihydro-3H-pyrazol-3-one [8] were prepared and characterized using FT-IR, 1H-NMR, 13C-NMR spectroscopic techniques and some physicochemical properties. These synthesized compounds were in vitro tested for their antimicrobial activity in the laboratory against several bacterial and fungus isolates. Each screened compounds exhibiting moderate to potent activity.


Cite this article:
Ayad Kareem Khan, Mohamed Dhiaa Hamdee. New Hydrochlorothiazide Derivatives: Synthesis, Characterization and Anti-Microbial Assessments. Research J. Pharm. and Tech. 2019; 12(12): 5848-5854. doi: 10.5958/0974-360X.2019.01014.X


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DOI: 10.5958/0974-360X 

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