Research Journal of Pharmacy and Technology

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0974-360X (Online)
0974-3618 (Print)


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New Hydrochlorothiazide Derivatives: Synthesis, Characterization and Anti-Microbial Assessments

Author(s): Ayad Kareem Khan, Mohamed Dhiaa Hamdee

Email(s): ayad@uomustansiriyah.edu.iq

DOI: 10.5958/0974-360X.2019.01014.X   

Address: Ayad Kareem Khan, Mohamed Dhiaa Hamdee
Department of Pharmaceutical Chemistry, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq.
*Corresponding Author

Published In:   Volume - 12,      Issue - 12,     Year - 2019

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ABSTRACT:
A new series of hydrochlorothiazide derivatives linked to heterogeneous rings such as 1,3,4-thiadiazine [3], 3,5-dihydroxypyrazolidin [4], 6-hydroxy-2-thioxo-1,3,4-thiadiazinane [5] and diazenyl-5-methyl-2,4-dihydro-3H-pyrazol-3-one [8] were prepared and characterized using FT-IR, 1H-NMR, 13C-NMR spectroscopic techniques and some physicochemical properties. These synthesized compounds were in vitro tested for their antimicrobial activity in the laboratory against several bacterial and fungus isolates. Each screened compounds exhibiting moderate to potent activity.


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Cite this article:
Ayad Kareem Khan, Mohamed Dhiaa Hamdee. New Hydrochlorothiazide Derivatives: Synthesis, Characterization and Anti-Microbial Assessments. Research J. Pharm. and Tech. 2019; 12(12): 5848-5854. doi: 10.5958/0974-360X.2019.01014.X


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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