Author(s): Sandip A. Bandgar, Namdeo R. Jadhav

Email(s): bandgarsandip21@gmail.com

DOI: 10.5958/0974-360X.2019.00994.6   

Address: Sandip A. Bandgar1*, Namdeo R. Jadhav2
1Ashokrao Mane College of Pharmacy, Peth-Vadgaon MS (India)
2Bharati Vidyapeeth College of Pharmacy, Kolhapur MS (India)
*Corresponding Author

Published In:   Volume - 12,      Issue - 12,     Year - 2019


ABSTRACT:
A new simple, precise spectrophotometric method was developed and validated for estimation of simvastatin from bulk and pharmaceutical formulation . In the present study, methanol as solvent and absorption maxima at 238 nm was used for estimation of simvastatin. The drug obeyed Beers law and showed good correlation. The linearity was observed between 2-18 µg/ml. The correlation coefficient was found to be 0.999. There was no significant difference in the precision analysis of simvastatin. The proposed method was validated statistically as per ICH guidelines with respect to recovery, linearity, Limit of detection (LOD) and Limit of quantitation (LOQ) and were found to be satisfactory. The method was developed and validated successfully for the quantitative analysis of simvastatin in bulk and pharmaceutical formulation.


Cite this article:
Sandip A. Bandgar, Namdeo R. Jadhav. Validated UV Spectrophotometric method for Estimation of Simvastatin in Bulk and Pharmaceutical Formulation. Research J. Pharm. and Tech. 2019; 12(12): 5745-5748. doi: 10.5958/0974-360X.2019.00994.6


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DOI: 10.5958/0974-360X 

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