Author(s): Rajasekaran Aiyalu, Karthikeyan Lakshmanan, Hari Baskar Balasubramanian, Arivukkarasu Ramasamy

Email(s): phytoarivu@gmail.com

DOI: 10.5958/0974-360X.2019.00992.2   

Address: Rajasekaran Aiyalu1, Karthikeyan Lakshmanan1, Hari Baskar Balasubramanian1, Arivukkarasu Ramasamy2*
1The Tamilnadu Dr. M.G.R. Medical University, Chennai, Tamil Nadu, India.
2Associate Professor, KMCH College of Pharmacy, Coimbatore, Tamil Nadu, India 641048
*Corresponding Author

Published In:   Volume - 12,      Issue - 12,     Year - 2019


ABSTRACT:
In this study we confirmed the hepatoprotective properties of the phytoconstituents Swertiamarin, Sweroside, Amarogentin, Gentiopicroside present in Gentianaceae family mainly the Iridoids and Seco-iridoids using molecular docking. This technique is used to check the interaction of phytoconstituents with hepatoprotective targets such as 1JEN - Human-S-Adenosyl methionine decarboxylase, 2OOL - Human sperimidine synthase, 2PO2 - Crystal structure of the alpha subunit of human-S-Adenosyl methionine Synthetase II, 1JBQ - Structure of human cystathionoine beta synthase a unique pyridoxal 5’ phosphate dependent heme protein, 2AZT - Crystal structure of H 176 N mutant of human glycine N-Methyl transferase, 2OBV - Crystal structure of the human-S-Adenosyl methionine synthase-I in complex with the product, 1093 - Methionine adenosyl transferase complexed with ATP and a L-Methionine analogues. Among the screened four phytoconstituents Sweroside exhibited best affinity against IJBQ with maximum binding energy of -38.97 and Gentio Picroside exhibit -30.53 with 1O93 target. Amarogentin also showed least affinity of 69.13 with 1JEN and JBQI. Thus, the present study provided the scientific validation for hepatoprotective activity of selected Iridoids and Secoiridoids.


Cite this article:
Rajasekaran Aiyalu, Karthikeyan Lakshmanan, Hari Baskar Balasubramanian, Arivukkarasu Ramasamy. Screening of Iridoids and Seco-iridoids in Gentianaceae Family against Liver corrective Targets using Molecular Docking studies. Research J. Pharm. and Tech. 2019; 12(12): 5735-5738. doi: 10.5958/0974-360X.2019.00992.2


Recomonded Articles:

Author(s): Nimbalkar V.V., Pansare P.M., Nishane B.B.

DOI: 10.5958/0974-360X.2015.00310.8         Access: Open Access Read More

Author(s): U.S Mahadeva Rao, Khamsah Suryati Mohd, Abdurrazaq Muhammad, Bashir Ado Ahmad, Mohaslinda Mohamad, Rosmawati Mat Ali

DOI: Not Available         Access: Open Access Read More

Author(s): Rekha Rajendran, R Hemachander, T Ezhilarasan, C Keerthana, DL Saroja, KV Saichand, Mohamed Gasim Abdullah

DOI: Not Available         Access: Open Access Read More

Author(s): Hayat M. Mukhtar, Vandna Kalsi

DOI: 10.5958/0974-360X.2018.00395.5         Access: Open Access Read More

Author(s): Josephin Nerling Rashida G., T. Venkatarathnakumar, R. Gowri, Ajithadhas Aruna

DOI: Not Available         Access: Open Access Read More

Author(s): Rupesh Pandey, Priyanka Upadhayay, Shiv Shankar Shukla

DOI:         Access: Open Access Read More

Author(s): Neha Rajput, Dinesh Sachan, Shikha Gangwar, Dipti Sachan

DOI: Not Available         Access: Open Access Read More

Author(s): Tarasankar Maity, Ayaz Ahmad, Nilanjan Pahari, Subarna Ganguli

DOI: Not Available         Access: Open Access Read More

Author(s): Karanje Abhijit Sampatrao, Kandale Jitendra Bhalchandra, Jadhav Ravindra, Patil Manohar

DOI: Not Available         Access: Open Access Read More

Author(s): Manisha N. Trivedi, Archana Khemani, Urmila D. Vachhani, Charmi P. Shah, D.D. Santani

DOI: Not Available         Access: Open Access Read More

Author(s): Jitendra Patel, A. Venkateshwar Reddy, G.S. Kumar, D. Satyasai4 B. Bajari, V. Nagarjuna

DOI: 10.5958/0974-360X.2017.00232.3         Access: Open Access Read More

Author(s): Subin Mary Zachariah, N. Aleykutty, Vidya Viswanad, Halima O.A.

DOI: Not Available         Access: Open Access Read More

Author(s): Zahraa Abdulelah Al Naqqash, Huda Khalil Al-Bazaz, Fatima Mahdi Salh, Shahad Qusay Ibraheem

DOI: 10.5958/0974-360X.2019.00013.1         Access: Open Access Read More

Author(s): T. Sheela Rani, V. Gopal, S. Seethalakshmi, K. Chitra

DOI: Not Available         Access: Open Access Read More

Author(s): Saba Shaikh, Ravi Dubey, Swati Dhande, Y.M Joshi, Vilasrao J. Kadam

DOI: Not Available         Access: Open Access Read More

Author(s): Pande S. D., Wagh A.S., Bhagure L.B., Patil S.G., Deshmukh A.R.

DOI: 10.5958/0974-360X.2015.00070.0         Access: Open Access Read More

Author(s): K. Hemalatha, K. Priya Darsini, D. Sunitha

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags