Research Journal of Pharmacy and Technology

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0974-360X (Online)
0974-3618 (Print)


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Synthesis and Antidepressant activity of 3, 4- dihydropyrimidin-2(1H)-ones

Author(s): Bedis S. P., Garud A. A., Patil C. P.

Email(s): jitendra_rsu@yahoo.co.in

DOI: 10.5958/0974-360X.2019.00962.4   

Address: Bedis S. P., Garud A. A., Patil C. P.
Rasiklal M. Dhariwal, Institute of Pharmaceutical Research & Education Research, Achary Anand Rishiji Marg, Chinchwad, Pune
*Corresponding Author

Published In:   Volume - 12,      Issue - 11,     Year - 2019

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ABSTRACT:
Derivatives of 3, 4- dihydropyrimidin-2(1H)-one and2, 5dioxo,4-aryl octahydroquinazolines were synthesized by microwave irradiation. The synthesized derivatives were characterized for physicochemical parameters and the spectroscopic studies. Compounds were screened for its antidepressant activity by using Tail Suspension Test (TST) and Forced Swim Test (FST) using fluoxetine as the standard. The duration of immobility measured in the control and animal groups treated with standard antidepressant drug (fluoxetine) and test drugs exhibited decrease in the immobility in both the models significantly and was comparable to the standard. Derivatives produced significant antidepressant activity in both the FST and TST in dose dependant manner.


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Cite this article:
Bedis S. P., Garud A. A., Patil C. P.. Synthesis and Antidepressant activity of 3, 4- dihydropyrimidin-2(1H)-ones. Research J. Pharm. and Tech. 2019; 12(11):5549-5553. doi: 10.5958/0974-360X.2019.00962.4


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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