Parameswari. P, Devika. R
Parameswari. P1*, Devika. R2
1Research Scholar, Department of Biotechnology, Sathyabama Institute of Science and Technology,
Chennai-600119 Dist- Kancheepuram, India.
2Professor, Department of Biotechnology, Aarupadai Veedu Institute of Technology, Paiyanoor,
Chennai-603104 Dist- Kancheepuram, India.
Volume - 12,
Issue - 11,
Year - 2019
Quercetin (a plant flavonoid) having a spot with polyphenol extensively disseminated in nature. Quercetin has aglycone structure and other flavonoid glycosides are rutin and quercetin. The examination displayed the quercetin compound was the best compound exhibiting higher confining imperativeness. In the present examination quercetin was isolated from the leaf concentrate of Artemisia nilagirica (Clarke) Pamp and the concentrate was certified through various instrumental examinations. An undertaking has been made for docking study practices with the extraordinary perceived characteristics MSX 2, HOX A10, HOX A5 and MAPK 14 for quieting proteins and SGK-1, BAX, ZFN 26 and ADM for anticancer. The docking results showed that there exists a coupling relationship between each protein and the goal of ligand-protein docking is to anticipate the overwhelming confining models of a ligand with a protein of known three dimensional structures. Docking considers yielded basic information concerning the presentation of the inhibitors in the coupling pocket of the objective proteins. The present work recognizes the potential remedy that concentrations against the receptor proteins as a characteristic solution to cure inflammation and cancer. The examination reveals that Quercetin can go utilized as medication to fix irritation and dangerous development. Fundamental point of this examination is to limit the dangerous impact of open medications to the common human cell. The examination displayed the Quercetin compound was the best compound appearing limiting imperativeness when differentiated Quercetin and moderating protein MAPK14 receptor leaving - 9.7 kcal/mol and anticancer proteins SGK-1 receptor is - 9.5 kcal/mol of confining essentialness. Taken together our results show that Quercetin may go about as alleviating and anticancer compound by affecting the NF-?B pathway. Further examinations in pre-clinical and clinical examinations are justified to illuminate the helpful capability of Quercetin for clinical use.
Cite this article:
Parameswari. P, Devika. R. In silico Molecular Docking Studies of Quercetin Compound against Anti-inflammatory and Anticancer Proteins. Research J. Pharm. and Tech. 2019; 12(11):5305-5309. doi: 10.5958/0974-360X.2019.00919.3
Parameswari. P, Devika. R. In silico Molecular Docking Studies of Quercetin Compound against Anti-inflammatory and Anticancer Proteins. Research J. Pharm. and Tech. 2019; 12(11):5305-5309. doi: 10.5958/0974-360X.2019.00919.3 Available on: https://rjptonline.org/AbstractView.aspx?PID=2019-12-11-31