K. Ishwar Bhat, Apoorva A, Abhishek Kumar, Pankaj Kumar
K. Ishwar Bhat, Apoorva A, Abhishek Kumar*, Pankaj Kumar
Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences,
NITTE (Deemed to be University), Paneer, Deralakatte-575018, Mangalore, Karnataka.
Volume - 12,
Issue - 11,
Year - 2019
A series of new 4-thiazolidinone derivatives were synthesized by reacting various coumarinyl schiff bases with thioglycollic acid. The intermediate coumarinyl schiff bases were synthesized by reacting 4-hydroxyl coumarin with various substituted anilines in alcohol medium. All the newly synthesized compounds were characterized on the basis of IR, 1H NMR and mass spectral data. All the newly synthesized compounds were evaluated for in-vitro antidiabetic activity by alpha-glucosidase inhibition assay. Most of the synthesised compounds showed good antidiabetic activity.
Cite this article:
K. Ishwar Bhat, Apoorva A, Abhishek Kumar, Pankaj Kumar. Synthesis and Antidiabetic Evaluation of Some New Coumarin Coupled 4-Thiazolidinone Derivatives. Research J. Pharm. and Tech. 2019; 12(11): 5215-5218. doi: 10.5958/0974-360X.2019.00902.8