Author(s): Navneet Kumar, Khushwant Kaur, Rajesh Kumar, Swadhin Sekhar Biswal, Abhishek Thakur, Pardeep Kumar Sharma, Charanjit Kaur, Gurvinder Singh

Email(s): guri_ph@yahoo.co.in

DOI: 10.5958/0974-360X.2019.00866.7   

Address: Navneet Kumar, Khushwant Kaur, Rajesh Kumar, Swadhin Sekhar Biswal, Abhishek Thakur, Pardeep Kumar Sharma, Charanjit Kaur, Gurvinder Singh*
Lovely School of Pharm. Sciences, Lovely Professional University, Phagwara, Punjab, India-144411
*Corresponding Author

Published In:   Volume - 12,      Issue - 10,     Year - 2019


ABSTRACT:
An analytical method has been developed by UV spectroscopy for the simple, precise, accurate and fast estimation of Miconazole nitrate in bulk and commercially available topical formulation. Miconazole nitrate shows good solubility in ethanol as compared to water; therefore, standard stock solution was prepared in ethanol. In the present study, 5 different concentrations of miconazole nitrate were prepared ranging from 2-10 µg/ml. The drug showed good absorbance at wavelength 232 nm. These solutions obeyed Beer’s law and correlation coefficient was found to be 0.999. The percentage recovery of 98.36% indicated high accuracy of the developed method. Less than 2% of relative standard deviation in intra-day as well as inter-day precision was observed. No interference of any foreign particles or excipients was noticeable throughout the assessment of drug in formulation. Limit of detection and limit of quantification of the method were found to be 1.868 µg/ml and 2.760 µg/ml, respectively. The developed validated method established the proposed method as specific, reliable, reproducible and cost-effective for the determination of miconazole nitrate in bulk and marketed formulation.


Cite this article:
Navneet Kumar, Khushwant Kaur, Rajesh Kumar, Swadhin Sekhar Biswal, Abhishek Thakur, Pardeep Kumar Sharma, Charanjit Kaur, Gurvinder Singh. Analytical Method Development and Validation for the Estimation of Miconazole Nitrate in Bulk and Marketed Topical Formulation. Research J. Pharm. and Tech. 2019; 12(10):4999-5003. doi: 10.5958/0974-360X.2019.00866.7


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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