ABSTRACT:
To assess the cognitive impairment in various conditions of hypothyroidism patients. The study design was a cross sectional observational case control study. The study site was carried out in the department of general medicine at Vivekanandha medical care Hospital, Tiruchengode. Patients of subclinical hypothyroidism without neurological disorder, Patients of overt hypothyroidism without neurological disorder, Normal Euthyroid persons were included in the study, Pediatrics Patients, Comatose patients, Chronic Illness patients, Patients with neurological disorder, pregnant women were excluded from the study. The average MMSE score of hypothyroid patients was 22.56±3.36, average MMSE score of control group is 24.94±2.48. When compared the both group shows (p <0.0001) extremely significant. Hypothyroidism patients have low MMSE score than euthyroid participants which reveals hypothyroidism is significantly associated with cognitive impairment. Present study also reveals patients who have chronic thyroid damage leads to higher risk of cognitive impairment.