Research Journal of Pharmacy and Technology

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0974-360X (Online)
0974-3618 (Print)


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In-Silico and in-Vitro Evaluation of Xanthine Oxidase Inhibition of Zingiber officinalae for Hypouricemic activity

Author(s): Sivakumar Muthusamy, Srikanth Jeyabalan

Email(s): srikanth.j@sriramachandra.edu.in

DOI: 10.5958/0974-360X.2019.00057.X   

Address: Sivakumar Muthusamy1, Srikanth Jeyabalan2
1Department of Pharmacology, Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University), Chennai, Tamil Nadu, India
2Assistant Professor, Department of Pharmacology Faculty of Pharmacy Sri Ramachandra Institute of Higher Education and Research (Deemed to be University) Chennai, India
*Corresponding Author

Published In:   Volume - 12,      Issue - 1,     Year - 2019

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ABSTRACT:
Zingiber officinale (ZO), traditionally known for its remedial potential, was examined on phytoconstituents analysis, antioxidant and xanthine oxidase inhibition by in-vitro analysis, followed by an in-silico study to identify the biological rationale. Results show that ethanolic extract of Zingiber officinale illustrated potential antioxidant to that of standard. DPPH ZO (IC50=42.09ug/mL), DPPH butylhydroxyltoluene (IC50=66.67ug/mL), nitric oxide ZO (IC50=28.36ug/mL), nitric oxide ascorbic acid (IC50=42.87??g/mL). Zingiber officinale extract inhibited the xanthine oxidase activity (IC50 = 188.5ug/mL) compared to allopurinol (IC50=499.2ug/mL), which showed competitive inhibition. The in-silico docking studies of the major phytoconstituents revealed by GC-MS analysis from this extract suggest that the inhibitory activity may be due to the combined effect of these compounds. These results suggest substantial reason for the evaluation of active compounds in in-vivo system for the management and treatment of gout as well as in the oxidative stress conditions.


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Cite this article:
Sivakumar Muthusamy, Srikanth Jeyabalan. In-Silico and in-Vitro Evaluation of Xanthine Oxidase Inhibition of Zingiber officinalae for Hypouricemic activity. Research J. Pharm. and Tech 2019; 12(1): 314-320. doi: 10.5958/0974-360X.2019.00057.X


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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