Author(s): Wrushali A. Panchale, Rajnandini Suroshe, Minakshi S. Rathod, Yuvraj L. Pandhare

Email(s): wpanchale@gmail.com

DOI: 10.5958/0974-360X.2019.00043.X   

Address: Wrushali A. Panchale*, Rajnandini Suroshe, Minakshi S. Rathod, Yuvraj L. Pandhare
MUP’s College of Pharmacy (B.Pharm), Degaon 444506, Dist. Washim, M.S., India
*Corresponding Author

Published In:   Volume - 12,      Issue - 1,     Year - 2019


ABSTRACT:
Aim of the present work was to develop Reversed phase HPLC method for simultaneous estimation of famotidine (FAM), paracetamol (PCT) and ibuprofen (IBU)in bulk drug and tablet formulation. Separation was carried out on Nucleosil C-18 (15cm, 4.6 mm I.D × 250 mm) using a mobile phase methanol and water (o-phosphoric acid, 0.05%) (83:17, v/v) at a flow rate of 0.7 ml/min. The detection wavelength was set at 270 nm. Retention time of FAM, PCT and IBU were found to be 1.81, 2.58 and 8.58 min respectively. Linear relationship was found in the concentration range of 0.5-3 µg/ml for FAM (r2 = 0.999), 5-25 µg/ml for PCT (r2 = 0.999) and 5–30 µg/ml for IBU (r2 = 0.999). The % purity was found to be 98.40±1.49, 99.86±0.27 and 100.31±0.76, for FAM, PCT and IBU, respectively. The proposed method was validated as per ICH Q2 (R1) guidelines. The mean % recoveries were found be 100.90±1.99, 99.96±0.97 and 100.51±1.72 for FAM, PCT and IBU, respectively.


Cite this article:
Wrushali A. Panchale, Rajnandini Suroshe, Minakshi S. Rathod, Yuvraj L. Pandhare. Chromatographic Analysis of Famotidine, Paracetamol and Ibuprofen from Tablet Formulation. Research J. Pharm. and Tech 2019; 12(1): 231-236. doi: 10.5958/0974-360X.2019.00043.X

Cite(Electronic):
Wrushali A. Panchale, Rajnandini Suroshe, Minakshi S. Rathod, Yuvraj L. Pandhare. Chromatographic Analysis of Famotidine, Paracetamol and Ibuprofen from Tablet Formulation. Research J. Pharm. and Tech 2019; 12(1): 231-236. doi: 10.5958/0974-360X.2019.00043.X   Available on: https://rjptonline.org/AbstractView.aspx?PID=2019-12-1-43


Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

1.3
2021CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags


Not Available