ABSTRACT:
Siddha system of medicine is one of the traditional systems of medicine which belongs to southern part of India. It widely uses herbs, metals and minerals as raw drugs for medicine preparation. The medicine which possesses metals and minerals are better to undergo physiochemical and toxicological analyses that help us to prove our drugs are nontoxic in nature. Pachai Karpoora Vadagam (PKV) is a Siddha Herbo-mineral formulation, prepared as per the Siddha literature Gunapadam Thaathu Seeva Vagupu. The phytochemical and physiochemical analysis like colour, odour, solubility, ash values and pH analysis were analyzed. The acute toxicity study was done in Swiss albino rats. The physiochemical of PKV revealed that all parameters were within normal range. The toxicity study did not exhibit any mortality in rats. No weight reduction and behavioral changes was noted. All internal organs were found to be normal in necropsy. Hence the Siddha formulation PKV is safe for human usage.