Author(s): Mohamed H. Sherif, Al-Shimaa M. Abas, Lobna A. Zaitoun

Email(s): dr_shmma@yahoo.com

DOI: 10.5958/0974-360X.2019.00033.7   

Address: Mohamed H. Sherif1, Al-Shimaa M. Abas2, Lobna A. Zaitoun2
1Chemistry Department, Faculty of Science, Zagazig University, Egypt
2Biochemistry Division, Chemistry Department, Faculty of Science, Zagazig University, Egypt
*Corresponding Author

Published In:   Volume - 12,      Issue - 1,     Year - 2019


ABSTRACT:
Background: Nephrotoxicity was reported in the initial clinical trials of contrast media. Aim of study: Our study was designed to evaluate the protective effect of ginger extract against nephrotoxicity induced by contrast agent. Material and Methods: Animals were divided into 5 groups as follow: Group1 (Control): They were not received any treatment during experiment period. Group2 (Ginger): Animals were deprived from water for 72 hours , then orally administrated with 400 mg/Kg/day of ginger extract for 72 hours. Group3 (protective): Animals were pre administrated orally with ginger extract with 400 mg/Kg for one week, then rats were deprived of water for 72 hours, then urografin was induced by a single (I.V.) at dose of 10mL per kg after that animals were orally administrated with 400 mg/Kg/day of ginger extract for 3 consecutive days. Group 4 (positive)(contrast media): Animals were induced by a single intravenous (I.V.) of urografin at dose of 10mL per kg after deprivation of water for 72 hours. Group 5(therapeutic): Animals rats were deprived of water for 72 hours, then Contrast-induced nephrotoxicity was induced (as group 4) , after that animals were post administrated with ginger extract 400 mg/Kg (for 3 days). Results: Administration contrast media caused significant elevation in serum urea, creatinine concentration, kidney tissue levels of MDA and NO. Also it caused significant increase in Cystain C , NGAL and TNFa levels. Also it significantly decreased SOD activity and GSH level. Treatment with Ginger extract restored the elevation of concentration of urea and creatinine, also oxidative stress markers in groups 3 and 5 and decreased Cystain C, NGAL and TNFa levels. Histopathological analysis confirmed that. Conclusion: ginger extract have a protective role in contrast media induced nephrotoxicity.


Cite this article:
Mohamed H. Sherif, Al-Shimaa M. Abas, Lobna A. Zaitoun. Ginger extract protect Iodinated Contrast Media Nephrotoxicity in rats through Modulation of Oxidative Stress, Cystain C, NGAL and TNF α. Research J. Pharm. and Tech 2019; 12(1): 175-184. doi: 10.5958/0974-360X.2019.00033.7

Cite(Electronic):
Mohamed H. Sherif, Al-Shimaa M. Abas, Lobna A. Zaitoun. Ginger extract protect Iodinated Contrast Media Nephrotoxicity in rats through Modulation of Oxidative Stress, Cystain C, NGAL and TNF α. Research J. Pharm. and Tech 2019; 12(1): 175-184. doi: 10.5958/0974-360X.2019.00033.7   Available on: https://rjptonline.org/AbstractView.aspx?PID=2019-12-1-33


Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

1.3
2021CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags


Not Available