Author(s): Saripah Salbiah Syed Abdul Azziz, Mat Ropi Mukhtar, A. Hamid A. Hadi, Yuhanis Mhd Bakri, Ahmed Kareem Obaid Aldulaimi, Khalijah Awang, Yumi Zuhanis Has-Yun Hashim

Email(s): saripah@fsmt.upsi.edu.my

DOI: 10.5958/0974-360X.2019.00022.2   

Address: Saripah Salbiah Syed Abdul Azziz*1, Mat Ropi Mukhtar2, A. Hamid A. Hadi2, Yuhanis Mhd Bakri1, Ahmed Kareem Obaid Aldulaimi1, Khalijah Awang2, Yumi Zuhanis Has-Yun Hashim3
1Department of Chemistry, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, 35900 Tanjong Malim, Perak, Malaysia
2Department of Chemistry, Faculty of Science, Universiti of Malaya, 50603 Kuala Lumpur, Malaysia
3Department of Biotechnology Engineering, Kulliyyah of Engineering, International Islamic University Malaysia, P.O. Box 10, 50728 Kuala Lumpur, Malaysia
*Corresponding Author

Published In:   Volume - 12,      Issue - 1,     Year - 2019


ABSTRACT:
A study on the alkaloidal composition on the Malaysian Annonaceae species, i.e Popowia perakensis King has been carried out. Barks of Popowia perakensis were extracted with hexane, dichloromethane and methanol, respectively. Dichloromethane extract further underwent the acid base treatment to give the alkaloidal crude extract. Isolation of compounds was carried out using various chromatography techniques including column chromatography and thin layer chromatography. Spectroscopic methods notably 1H, 13C NMR, IR, UV and GC-MS spectroscopy were utilized to identify pure compounds in addition to comparison of reported data. Two azaanthraquinones alkaloids namely cleistopholine 1 and 6-methoxycleistopholine 2 together with simple isoquinolone alkaloid, N-methylcorydaldine 3 had been isolated. All three alkaloids are known but they were isolated for the first time from this species. Cleistopholine 1 was tested for Dipeptidyl peptidase IV (DPP IV) inhibition to investigate its potential antidiabetic activities. Results revealed that this compound showed quite weak (6.26 %) inhibitory activities as compared to the positive control, Diprotin A (81.46 %). The quantity of the other two compounds was insufficient for the screening purposes.


Cite this article:
Saripah Salbiah Syed Abdul Azziz, Mat Ropi Mukhtar, A. Hamid A. Hadi, Yuhanis Mhd Bakri, Ahmed Kareem Obaid Aldulaimi, Khalijah Awang, Yumi Zuhanis Has-Yun Hashim. Alkaloids from Popowia perakensis King and their potential as Dipeptidyl peptidase IV (DPP IV) inhibitors. Research J. Pharm. and Tech 2019; 12(1): 113-116. doi: 10.5958/0974-360X.2019.00022.2

Cite(Electronic):
Saripah Salbiah Syed Abdul Azziz, Mat Ropi Mukhtar, A. Hamid A. Hadi, Yuhanis Mhd Bakri, Ahmed Kareem Obaid Aldulaimi, Khalijah Awang, Yumi Zuhanis Has-Yun Hashim. Alkaloids from Popowia perakensis King and their potential as Dipeptidyl peptidase IV (DPP IV) inhibitors. Research J. Pharm. and Tech 2019; 12(1): 113-116. doi: 10.5958/0974-360X.2019.00022.2   Available on: https://rjptonline.org/AbstractView.aspx?PID=2019-12-1-22


Recomonded Articles:

Author(s): Rekha Rajendran, R Hemachander, T Ezhilarasan, C Keerthana, DL Saroja, KV Saichand, Mohamed Gasim Abdullah

DOI: Not Available         Access: Open Access Read More

Author(s): Mayanka Singh, Manoj Charde, Rajesh Shukla, Rita M. Charde

DOI: Not Available         Access: Open Access Read More

Author(s): Vandana Gautam, Dhriti Kapoor, Saroj Arora, Renu Bhardwaj*

DOI: 10.5958/0974-360X.2016.00166.9         Access: Open Access Read More

Author(s): Rituraj Singh Chundawat, Y.S. Sarangdevot, R.P.S. Rathore, Dharmendra Singh Sisodiya, Udaibhan Singh Rathore

DOI:         Access: Open Access Read More

Author(s): Anket Sharma, Vinod Kumar, Parminder Kaur, Ashwani Kumar Thukral, Renu Bhardwaj

DOI: 10.5958/0974-360X.2015.00299.1         Access: Open Access Read More

Author(s): Mahadeva Rao U.S., Suganya M. Utharkar, C. Shanmuga Sundaram

DOI: 10.5958/0974-360X.2015.00307.8         Access: Open Access Read More

Author(s): Dharmendra Kumar Kushwah, Prakash Yashwant Kohle, Rajesh D Joshi, Bakul Rajyaguru, Rajeev Pandey, Brajesh Vishwakarma

DOI: Not Available         Access: Open Access Read More

Author(s): Basanti Majhi, Kunja Bihari Satapathy, Sagar Kumar Mishra

DOI: 10.5958/0974-360X.2019.00202.6         Access: Open Access Read More

Author(s): Oruganti Sai Koushik, V. Himaja, P. Srinivasa Babu, Ramadoss Karthikeyan

DOI: 10.5958/0974-360X.2015.00298.X         Access: Open Access Read More

Author(s): Khairi M. S. Fahelelbom, Moawia M. M. Al-Tabakha, Nermin A. M. Eissa, Dana Emad Eddin Obaid, Sadik Sayed

DOI: 10.5958/0974-360X.2020.00470.9         Access: Open Access Read More

Author(s): YK Naidu, Raghunadha Reddy S, Koteswara Rao Divi, MP Kalyan Reddy, I Sarath Chandiran, KN Jayaveera

DOI: Not Available         Access: Open Access Read More

Author(s): Ghoufran Kawas, Mohammad Marouf, Oussama Mansour, Amir Alhaj Sakur

DOI: 10.5958/0974-360X.2018.00396.7         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags