ABSTRACT:
Etodolac is a non-steroidal anti-inflammatory drug used in treatment of pain, swelling and joint stiffness from arthritis. Etodolac is BCS class II drug with low solubility and high permeability. Pharmaceutical co-crystals of Etodolac were prepared with 4-amino benzoic acidto improve physicochemical properties like solubility, stability and bioavailability of drug. Co-crystals of Etodolac with 4-amino benzoic acid was prepared by using solvent drop grinding method. Newly prepared crystalline form was characterized by Infrared spectroscopy, X-ray diffraction and differential scanning calorimetryto confirm purity and homogeneity of co-crystals. Co-crystals of Etodolac showed enhancement in solubility by 5.12 folds as compared with pure drug. Etodolac co-crystals tablets were prepared which showedbetter dissolution rate as compared with marketed formulation. The study showed that co-crystals of Etodolac with 4-amino benzoic acid can bea better and emerging alternative to modify and enhance physicochemical properties of pure drug.