ABSTRACT:
Background: Reactive oxygen and nitrogen species produced via cellular metabolism and from exposure to environmental pro-oxidants appear to contribute to the pathogenesis of chronic disease via free radical damage to lipids, nucleic acids, and proteins. Literature review: Morinda citrifolia (MC) fruit is rich in phytochemicals necessary for treatment of diabetes. Objective: The purpose of this study was to investigate the effect of MC fruit extracts’ free radical scavenging, and reducing potentials as well as inhibitory effect on a-amylase and a-glucosidase. Methods: The of percentage yield, phytochemical screening (both qualitative and quantitative), in vitro antioxidant and antidiabetic assays, and kinetic studies were performed with different solvent extracts of MC fruit pulp. Results: MC inhibits a-glucosidase and a- amylase enzymes in the in vitro studies. The antioxidant and reducing potentials of the fruit extract gives strong biochemical rationale of their therapeutic potential. Conclusion: Therefore the fruit extract of MC may play an important role in the development of nutraceuticals and also in the management of oxidative stress induced diabetes.
Cite this article:
Mahadeva Rao US.. In Vitro Free Radical Scavenging and Reducing Potentials as well as Inhibitory Potential on α-Amylase and α-Glucosidase Activities of Fruit of Morinda citrifolia (Rubiaceae). Research J. Pharm. and Tech 2018; 11(9): 4135-4142. doi: 10.5958/0974-360X.2018.00760.6
Cite(Electronic):
Mahadeva Rao US.. In Vitro Free Radical Scavenging and Reducing Potentials as well as Inhibitory Potential on α-Amylase and α-Glucosidase Activities of Fruit of Morinda citrifolia (Rubiaceae). Research J. Pharm. and Tech 2018; 11(9): 4135-4142. doi: 10.5958/0974-360X.2018.00760.6 Available on: https://rjptonline.org/AbstractView.aspx?PID=2018-11-9-75