Author(s): Khudhayer J. Kadem, Murad G. Munahi

Email(s): khudheyerbabel@yahoo.com

DOI: 10.5958/0974-360X.2018.00745.X   

Address: Khudhayer J. Kadem, Murad G. Munahi
Department of Chemistry, College of Science, University of Babylon, Iraq
*Corresponding Author

Published In:   Volume - 11,      Issue - 9,     Year - 2018


ABSTRACT:
A series of Schiff’s bases and their novel derivatives (Oxazepines) have been synthesized , 4-hydroxy-3-methoxy benzaldehyde (vanillin) was condensed with different amines to produce the Schiff’s bases in the presence of glacial acetic acid as a catalyst or KOH , novel five 1,3-oxazepine derivatives have been synthesized through reaction of Schiff’s bases with succinic anhydride and maleic anhydride using acidic catalyst. The identification was performed using, FT-IR and1H-NMRspectroscopies. The synthesized1,3-oxazepine derivatives were biologically screened against gram positive (Staphylococcus aureus) and gram negative bacteria (Escherichia coli) . The results was showed excellent to moderate anti-bacterial activity.


Cite this article:
Khudhayer J. Kadem, Murad G. Munahi. Synthesis, Characterization and Biological Evaluation of some Novel 1,3 Oxazepine derivatives from Vanillin Schiff’s Bases. Research J. Pharm. and Tech 2018; 11(9): 4047-4050. doi: 10.5958/0974-360X.2018.00745.X


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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