Author(s):
Ranee Kumari, Abhishek Kumar
Email(s):
bhatishwar@yahoo.co.in
DOI:
10.5958/0974-360X.2018.00729.1 
Address:
K. Ishwar Bhat*, B. C. Revanasiddappa, M. Vijay Kumar, Banylla Felicity,
Ranee Kumari, Abhishek Kumar
Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences of NITTE
(Deemed to be University), Paneer, Deralakatte, Mangalore-575 018, Karnataka, India
*Corresponding Author
Published In:
Volume - 11,
Issue - 9,
Year - 2018
ABSTRACT:
A new series of Chalcones (2a-i) were prepared by Claisen-Schmidth Condensation reaction involving substituted aromatic aldehydes and aromatic ketones in alcohol medium, in presence of 40% NaOH as base. The title compounds Pyrazolines (3a-i) were synthesized by reacting Chalcones (2a-i) and 2-thiophene carbohydrazide (1) in glacial acetic acid medium. The final synthesized compounds were screened for their In-vitro anti-inflammatory activity by egg albumin denaturation method and protein denaturation method. The structures of the newly synthesized compounds were assigned on the basis of IR, 1H-NMR and Mass spectral data. The compounds 3b, 3c, 3d and 3f also showed good inhibition when compared to the standard diclofenac sodium
Cite this article:
Ranee Kumari, Abhishek Kumar. Synthesis and In-Vitro Anti-Inflammatory Activity of New Pyrazoline Derivatives. Research J. Pharm. and Tech 2018; 11(9): 3969-3972. doi: 10.5958/0974-360X.2018.00729.1
Cite(Electronic):
Ranee Kumari, Abhishek Kumar. Synthesis and In-Vitro Anti-Inflammatory Activity of New Pyrazoline Derivatives. Research J. Pharm. and Tech 2018; 11(9): 3969-3972. doi: 10.5958/0974-360X.2018.00729.1 Available on: https://rjptonline.org/AbstractView.aspx?PID=2018-11-9-44