Author(s): Akhil Nair, Harini R, Melissa P, Krupali Shah, Usha Y Nayak*, Mahalaxmi R, Vamshi Krishna T

Email(s): usha.nayak@gmail.com

DOI: 10.5958/0974-360X.2018.00722.9   

Address: Akhil Nair, Harini R, Melissa P, Krupali Shah, Usha Y Nayak*, Mahalaxmi R, Vamshi Krishna T
Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India–576104
*Corresponding Author

Published In:   Volume - 11,      Issue - 9,     Year - 2018


ABSTRACT:
The aim of the work was to prepare co-crystals of irbesartan (IBS), a BCS Class II drug to enhance its aqueous solubility and bioavailability. The solvent evaporation method was used to prepare co-crystals by using different co-formers and varying the drug to co-former molar ratios. Succinic acid and benzoic acid co-crystals were formed with good physicochemical properties. The solid-state characterization of co-crystals was studied by FTIR, DSC, and XRD. The co-crystals were evaluated for the saturation solubility and dissolution studies. There was a 2-fold increase in the aqueous solubility and 4-8 fold increase in dissolution rate of co-crystals. Solid state characterizations indicated there was no change in the chemical nature of the co-crystals compared to pure drug. Presence of crystalline co-former induced crystallinity to the developed co-crystals. Thus, developed co-crystals were found to be a suitable alternative to increase the solubility and dissolution rate of IBS.


Cite this article:
Akhil Nair, Harini R, Melissa P, Krupali Shah, Usha Y Nayak*, Mahalaxmi R, Vamshi Krishna T. Development and characterization of Irbesartan Co-Crystals. Research J. Pharm. and Tech 2018; 11(9): 3932-3936. doi: 10.5958/0974-360X.2018.00722.9


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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