Author(s): Mohd Faeiz Pauzi, Siti Norazlina Juhari, Mohd Nikman Ahmad, Farid Che Ghazali

Email(s): shekhar_bio@yahoo.co.in

DOI: 10.5958/0974-360X.2018.00710.2   

Address: Mohd Faeiz Pauzi1, Siti Norazlina Juhari1, Mohd Nikman Ahmad2, Farid Che Ghazali2
1Medical Faculty, Universiti Sultan Zainal Abidin, Medical Campus, Jalan Sultan Mahmud, 20400 Kuala Terengganu, Malaysia.
2 Medical Campus, Universiti Sains, Malaysia,16150 Kubang Kerian, Malaysia.
*Corresponding Author

Published In:   Volume - 11,      Issue - 9,     Year - 2018


ABSTRACT:
This study was design to investigate the effect of total sulfated GAG from integument body wall of sea cucumber Stichopus vastus on inflammatory mediators and tissue healing on rodents with full thickness burn injury.Twelve male Sprague-dawley rats weighting 350-400 grams were distributed randomly into two groups. Six rats in group A received 5 ml/kg/day intraperitoneal total sulfated GAG from S.vastusfor 5 days, while control group received phosphate buffered saline (PBS). Level ofIL-10 and IL-12 were measured at day 1, 6 and 12. The level of IL-10 revealed significantly (p<0.05) higher andthe level of IL-12 was reduced significantly (p<0.05) in sulfated GAG treated group. Data suggested that sulfated GAG from S. vastus integument body wall increase anti-inflammatory cytokine and reduce pro-inflammatory cytokine. Microscopic evaluation showed reduced neutrophils infiltration with enhanced proliferation of fibroblasts and angiogenesis (p<0.05) in the sulfated GAG treated group. Sulfated GAG from S. vastus integument body wall has impact on the outcome of wound healing process by increasing the level of anti-inflammatory cytokine, IL-10 and reduced level of pro-inflammatory cytokine, IL-12 and positive effect on fibroblast proliferation and angiogenesis process.


Cite this article:
Mohd Faeiz Pauzi, Siti Norazlina Juhari, Mohd Nikman Ahmad, Farid Che Ghazali. Effects of Glycosaminoglycans Extrat from sea Cucumber Stichopus vastus on Inflammatory Mediators and Tissue Healing on Rodents with full Thickness Burn Injury. Research J. Pharm. and Tech 2018; 11(9): 3874-3880. doi: 10.5958/0974-360X.2018.00710.2


Recomonded Articles:

Author(s): Deepak Karki, Gururaj S. Kulkarni, Shivakumar Swamy, Sheeba FR

DOI: 10.5958/0974-360X.2017.00750.8         Access: Open Access Read More

Author(s): B. Thawkar, M. Kale, M. Oswal, K. Maniyar, K. Kadam, S. Kamat

DOI: 10.5958/0974-360X.2016.00044.5         Access: Open Access Read More

Author(s): Sandesh More, Javed Mirza, Nanasaheb Kale, Mayur Gandhi, Rakesh Chaudhari

DOI: Not Available         Access: Open Access Read More

Author(s): Priya P. Munshi, D.S. Mohale, R. Akkalwar, A.V. Chandewar

DOI: Not Available         Access: Open Access Read More

Author(s): R. Suresh, D. Benitojohnson, C. Maheswari, R. Venkatnarayanan, R.Manavalan

DOI: 10.5958/0974-360X.2017.00128.7         Access: Open Access Read More

Author(s): Rupesh Pandey, Priyanka Upadhayay, Shiv Shankar Shukla

DOI:         Access: Open Access Read More

Author(s): Jong-Im Kim, Sun Kyung Kim, Hyunjoo Kim, Sunae Kim, Taehui Kim, Keumok Park, Bohyun Kim

DOI: 10.5958/0974-360X.2017.00544.3         Access: Open Access Read More

Author(s): Karanje Abhijit Sampatrao, Kandale Jitendra Bhalchandra, Jadhav Ravindra, Patil Manohar

DOI: Not Available         Access: Open Access Read More

Author(s): DK Golwala, LD Patel, SB Bothara, SK Vaidya, AR Sahu, S Kumar

DOI: Not Available         Access: Open Access Read More

Author(s): Sahu Sudeep, Dey Tathagata, Khaidem Somila, Y Jyothi

DOI: Not Available         Access: Open Access Read More

Author(s): Manju Rawat, SJ Daharwal, Deependra Singh

DOI:         Access: Open Access Read More

Author(s): Suman Katteboina and VSR Chandrasekhar P

DOI: Not Available         Access: Open Access Read More

Author(s): Suralkar Anupama A., Jadhav Asha S., Vaidya Gayatri S., Sharma Ashish, Meghraj Chaudary, Vivek Bhora

DOI: Not Available         Access: Open Access Read More

Author(s): Soumya Khare, Amit Alexander, Ajazuddin, Nisha Amit

DOI: Not Available         Access: Open Access Read More

Author(s): Jennifer F, Thomas AK, Fernandes R, Subrhamanyam EVS

DOI: Not Available         Access: Open Access Read More

Author(s): Charde RM, Charde MS, Fulzele SV, Satturwar PM, Kasture AV, Joshi SB

DOI: Not Available         Access: Open Access Read More

Author(s): Tejashree N. Hagawane, Aashish M. Mahuvakar, Rajiv V. Gaikwad, Nilima A. Kshirsagar

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 


Recent Articles




Tags