ABSTRACT:
Tuberculosis is a disease caused by bacteria Mycobacterium tuberculosis that most often affect the lungs. Due to overuse of antibiotic, development of resistance is occurred, diseases which were once upon a time easily curable has become one major concern of the world. Microorganism like bacteria can quickly adapt resistance against the action of the antibiotic which makes it difficult to kill them. Since it is very time consuming and expensive to come up with new antibiotics, scientists are trying to come up with new methods like bacteriophage therapy, vaccinations, etc. This reduces the chance of development of resistance and minimizes the use of antibiotic. Multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis are generally thought to have high mortalityrates. The World Health Organization’s (WHO) global tuberculosis programmed in 1993 declared tuberculosis a global emergency and began promoting a management strategy called directly observed therapy short course (DOTS). The problem of antibiotic resistance can be minimized only by concerted efforts of all members of society for ensuring the continued efficiency of antibiotic.