ABSTRACT:
A new RP-HPLC method has been developed and validated for the simultaneous determination of Ketorolac tromethamine and Fluorometholone pharmaceutical formulations. Shimadzu Model CBM-20A/20 Alite with C8 Phenomenex column (250 mm × 4.6 mm i.d., 5 µm particle size) was used for the proposed work with a mixture of 0.1M ammonium formate and methanol as mobile phase and flow rate 0.8 ml/min (UV detection at 241 nm). The linear regression equation was found to be y = 35207x + 29529 R² = 0.9995 for Fluorometholone and y = 68207x + 57590 R² = 0.9997 for Ketorolac tromethamine and the method was validated.
Cite this article:
Sunkara Mrunal Chaithanya, Mukthinuthalapati Mathrusri Annapurna. Method Development and Validation of a new RP-HPLC method for the simultaneous Assay of Ketorolac Tromethamine and Fluorometholone. Research J. Pharm. and Tech 2018; 11(7): 3119-3122. doi: 10.5958/0974-360X.2018.00572.3
Cite(Electronic):
Sunkara Mrunal Chaithanya, Mukthinuthalapati Mathrusri Annapurna. Method Development and Validation of a new RP-HPLC method for the simultaneous Assay of Ketorolac Tromethamine and Fluorometholone. Research J. Pharm. and Tech 2018; 11(7): 3119-3122. doi: 10.5958/0974-360X.2018.00572.3 Available on: https://rjptonline.org/AbstractView.aspx?PID=2018-11-7-71