Research Journal of Pharmacy and Technology

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0974-360X (Online)
0974-3618 (Print)


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Method Development and Validation of a new RP-HPLC method for the simultaneous Assay of Ketorolac Tromethamine and Fluorometholone

Author(s): Sunkara Mrunal Chaithanya, Mukthinuthalapati Mathrusri Annapurna

Email(s): mrunal.chaitanya@gmail.com

DOI: 10.5958/0974-360X.2018.00572.3   

Address: Sunkara Mrunal Chaithanya*, Mukthinuthalapati Mathrusri Annapurna
Department of Pharmaceutical Analysis and Quality Assurance, GITAM Institute of Pharmacy,
GITAM (Deemed to be University), Visakhapatnam-530045, India
*Corresponding Author

Published In:   Volume - 11,      Issue - 7,     Year - 2018

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ABSTRACT:
A new RP-HPLC method has been developed and validated for the simultaneous determination of Ketorolac tromethamine and Fluorometholone pharmaceutical formulations. Shimadzu Model CBM-20A/20 Alite with C8 Phenomenex column (250 mm × 4.6 mm i.d., 5 µm particle size) was used for the proposed work with a mixture of 0.1M ammonium formate and methanol as mobile phase and flow rate 0.8 ml/min (UV detection at 241 nm). The linear regression equation was found to be y = 35207x + 29529 R² = 0.9995 for Fluorometholone and y = 68207x + 57590 R² = 0.9997 for Ketorolac tromethamine and the method was validated.


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Cite this article:
Sunkara Mrunal Chaithanya, Mukthinuthalapati Mathrusri Annapurna. Method Development and Validation of a new RP-HPLC method for the simultaneous Assay of Ketorolac Tromethamine and Fluorometholone. Research J. Pharm. and Tech 2018; 11(7): 3119-3122. doi: 10.5958/0974-360X.2018.00572.3

Cite(Electronic):
Sunkara Mrunal Chaithanya, Mukthinuthalapati Mathrusri Annapurna. Method Development and Validation of a new RP-HPLC method for the simultaneous Assay of Ketorolac Tromethamine and Fluorometholone. Research J. Pharm. and Tech 2018; 11(7): 3119-3122. doi: 10.5958/0974-360X.2018.00572.3   Available on: https://rjptonline.org/AbstractView.aspx?PID=2018-11-7-71


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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