ABSTRACT:
Aim and objectives: The drug-drug interaction is the primary cause of irrationality prescriptions mostly due to polypharmacy. Drug interactions have caused by the two or more drugs or other substances taken by the same patient. Due to widespread of therapeutic medications and polypharmacy, drug interactions are enormous. The aim of the study to evaluate and assess the drug-drug interactions in tertiary care teaching hospital in South India. Methods: A Retrospective study has conducted by enrolling the prescriptions of outpatients in the hospital who came for patient counselling to Drug information centre during the year of 2017. Results: In that Out of 350 prescriptions, 110 orders were found to have drug-drug interactions (p<0.0001), in that 33 (21%) were found to be minor, 110 (70%) moderate, 15 (9%) significance major interactions which may require some therapeutic interventions or monitoring. Conclusion: The frequently occurring drug interactions are seen in Anti-hypertensive drugs, Diuretics, Proton pump Inhibitors and Antibiotics.