Author(s): Larysa V. Lenchyk, Dovran Ovezgeldiyev, Olga V. Shapoval, Sergii V. Baiurka, Abderrahim Ayaou

Email(s): larysa.lenchyk@gmail.com

DOI: 10.5958/0974-360X.2018.00559.0   

Address: Larysa V. Lenchyk1, Dovran Ovezgeldiyev2, Olga V. Shapoval3, Sergii V. Baiurka4, Abderrahim Ayaou5
1Doctor of Science (Pharmacy), Associate Professor, Department of Chemistry of Natural Compounds National University of Pharmacy,. Pushkinska, 53, Kharkov, 61002 Ukraine.
2Master of Pharmacy, National University of Pharmacy, Pushkinska, 53, Kharkov, 61002 Ukraine. 3PhD (Candidate) of Biological Sciences, Assistant Professor, Department of Pharmacology and Prescription writing Kharkiv National Medical University Nauky Avenue, 4, Kharkiv, 61022 Ukraine. 4Doctor of Science (Pharmacy), Professor Head of the Department of Drug and Analytical Toxicology, National University of Pharmacy, Pushkinska, 53, Kharkov, 61002 Ukraine.
5Student of National University of Pharmacy Elsässerstrasse 39, 4056 Basel-Switzerland.
*Corresponding Author

Published In:   Volume - 11,      Issue - 7,     Year - 2018


ABSTRACT:
Qualitative composition and content of flavonoids and hydroxycinnamic acids in cherry (Prunus cerasus) fruits extract have been studied by HPLC, system Shimadzu LC-20 Prominence module system equipped with LC-20AD quaternary pump, ???-20? column oven, SIL-20A autosampler, SPD-M20A diode-array detector, Luna C 18 (4.6mm×150mm, i.d. 5 mkm) column from Phenomenex®. 5 phenolic compounds were identified as flavonoid glycosides and hydroxycinnamic acids: chlorogenic acid (1.88%), quercitrin (1.69%), and rutin (1.11%) in high amount. It also contains tannins: gallic acid (0.07%), and catechin (0.23%). The total amount of determined phenolic compounds in cherry extract was 4.99%. The ratio of flavonoids to hydroxycinnamic acids was 3:2. Toxicity, diuretic activity, rheological properties of blood and membrane stabilizing activity were determined. Rats were randomly divided into 2 groups: control group (given water) and experimental group (given Cherry extract). Results show diuretic, hypouricosemic, and membrane-stabilizing effects due to improvement of kidney filtration and suppressing water reabsorption, excretion of uric acid and creatinine from the body and reducing the degree of hemolysis of red blood cells and preventing damage to erythrocyte membranes. Therefore, according to our study, cherry fruit extract might potentially be used in treatment of various chronic diseases (e.g. gout).


Cite this article:
Larysa V. Lenchyk, Dovran Ovezgeldiyev, Olga V. Shapoval, Sergii V. Baiurka, Abderrahim Ayaou. Study of Chemical Composition and Diuretic Activity of Cherry Fruit Extract. Research J. Pharm. and Tech 2018; 11(7): 3036-3042. doi: 10.5958/0974-360X.2018.00559.0

Cite(Electronic):
Larysa V. Lenchyk, Dovran Ovezgeldiyev, Olga V. Shapoval, Sergii V. Baiurka, Abderrahim Ayaou. Study of Chemical Composition and Diuretic Activity of Cherry Fruit Extract. Research J. Pharm. and Tech 2018; 11(7): 3036-3042. doi: 10.5958/0974-360X.2018.00559.0   Available on: https://rjptonline.org/AbstractView.aspx?PID=2018-11-7-58


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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