Author(s): Suresh K. Sahu, Alpana Ram

Email(s): ramalpana@rediffmail.com

DOI: 10.5958/0974-360X.2018.00557.7   

Address: Suresh K. Sahu, Alpana Ram*
Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur (CG) - 495009 INDIA
*Corresponding Author

Published In:   Volume - 11,      Issue - 7,     Year - 2018


ABSTRACT:
Linezolid (LZD) is a recommended antibiotic drug for the treatment of deep skin infections in diabetic conditions. However, the application of LZD is limited to indefinite drug release topically. The aim of this study was to develop and characterize a novel LZD loaded ethosomes and compare with LZD loaded liposomes and hydroethanolic drug solution for topical delivery to provide safe and effective treatment against skin infections during diabetes. In this study, the LZD loaded ethosomes was prepared by cold method. It was compared with liposomes and hydroethanolic solution of linezolid, and characterized for particle size, shape, polydispersity, entrapment efficiency and zeta potential. In vitro release profile was determined by dialysis bag and skin penetration effect was evaluated using Franz diffusion cell. In vivo skin irritation test was performed using animal skin. Animals were made diabetic by administering Streptozotocin intraperitonealy. Antimicrobial activity against Staphylococcus aureus was determined by using cup plate method and also checked on animals. The results showed that among all formulations LZD loaded ethosomes had better entrapment efficiency (67.32%), polydispersity (0.21), spherical shape, size (299.86 nm), zeta potential (-44.2 mV) and highest in vitro release (98 ± 1.5% in 48 h) and drug permeation (46.6±1.6% % within 24 h). Low irritation score (0.72) revealed that ethosomes was non-irritant. Antimicrobial assay indicated that linezolid loaded ethosomes had better inhibitory effect against S. aureus and prevented deep skin infections. LZD loaded ethosomes was found more effective in treatment of skin and soft tissue infections in comparison to convectional liposomes and hydroethanolic drug solution. It may be an ideal drug formulation for treating deep skin infections during diabetes due to its better skin retention property and lesser side effects.


Cite this article:
Suresh K. Sahu, Alpana Ram.Evaluation of Linezolid Loaded Ethosomes for Treatment of Deep Skin Infections in Diabetic Model. Research J. Pharm. and Tech 2018; 11(7): 3023-3030. doi: 10.5958/0974-360X.2018.00557.7


Recomonded Articles:

Author(s): Kumkum Sarangdevot, Bhawani Singh Sonigara, Amul Mishra, K. C. Gupta, Surbhi Sharma

DOI: Not Available         Access: Open Access Read More

Author(s): Amutha K*, Ashok Kumar A, Godavari A

DOI: 10.5958/0974-360X.2017.00100.7         Access: Open Access Read More

Author(s): Nada Khazal Kadhim Hindi, Iman Fadhil Abdul-Husin, Zainab Khudhur Ahmad Al-Mahdi, Ruqaya M. J. Ewadh, Ahmed Obaid Hossain, Mohanad Jawad Kadhim, Ali Hussein F. Alnasraui, Amean A. Al-Yaseri

DOI: 10.5958/0974-360X.2017.00343.2         Access: Open Access Read More

Author(s): Surendra Nath Pandeya, Rajeev Kumar, Arun Kumar, Ashish Kumar Pathak

DOI: Not Available         Access: Open Access Read More

Author(s): Pankaj Kumar, Jennifer Fernandes, Abhishek Kumar

DOI: 10.5958/0974-360X.2017.00023.3         Access: Open Access Read More

Author(s): AK Jain, Naveen Sharma, Amit Upadhyay, Ashish Dixit

DOI: Not Available         Access: Open Access Read More

Author(s): Manisha N. Trivedi, Archana Khemani, Urmila D. Vachhani, Charmi P. Shah, D.D. Santani

DOI: Not Available         Access: Open Access Read More

Author(s): Kulkarni Anup, Kale Mohan, Sarode Suraj, Firke Sandip, Firke Bhushan, Warke Prashant

DOI: Not Available         Access: Open Access Read More

Author(s): A. Kaura, Lalit Sharma, V. J. Dhar

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags