Author(s): Mukthinuthalapati Mathrusri Annapurna, Debi Prasad Pradhan, Krishna Chaitanya Routhu

Email(s): mannapurna.mukthinuthalapati@gitam.edu

DOI: 10.5958/0974-360X.2018.00554.1   

Address: Mukthinuthalapati Mathrusri Annapurna*, Debi Prasad Pradhan, Krishna Chaitanya Routhu
Department of Pharmaceutical Analysis and Quality Assurance, GITAM Institute of Pharmacy,
GITAM (Deemed to be University), Visakhapatnam, Andhra pradesh-530045, India.
*Corresponding Author

Published In:   Volume - 11,      Issue - 7,     Year - 2018


ABSTRACT:
Abiraterone is used for the treatment of prostate cancer for men. Abiraterone is available as Abiraterone acetate. Food and drug administration approves Abiraterone for treatment of men with advanced prostate cancer. A new stability indicating RP-HPLC method has been proposed for the quantification of Abiraterone. Capcell PAK C18 column (100 mm × 4.6 mm i.d., 3 µm particle size) was used for the chromatographic study of Abiraterone acetate with mobile phase mixture 0.1 % acetic acid and acetonitrile (11:89 v/v) (Flow rate: 1.2 mL/min) on Shimadzu Model CBM-20A/20 Alite HPLC system (PDA detector). Forced degradation studies were performed and the method was validated.


Cite this article:
Mukthinuthalapati Mathrusri Annapurna, Debi Prasad Pradhan, Krishna Chaitanya Routhu. Stability Indicating RP-HPLC method for the determination of Abiraterone (An Anti-Cancer Drug). Research J. Pharm. and Tech 2018; 11(7): 3007-3012. doi: 10.5958/0974-360X.2018.00554.1


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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