Author(s): Hemlata Sahu, Amit Alexander, Swapnil Gupta, Pooja Yadav, Hemlata Thapa, Tripti Banjare, Palak Agrawal, Akansha Bhandarkar, Aditi Bhatt, Shradha Devi Diwedi, Pankaj Sahu, Siddharth Kumar Sahu, Kailash Sahu, Deeksha Dewangan, Deepika, Mukesh Sharma, D. K. Tripathi, Ajazuddin

Email(s): write2ajaz@gmail.com , ajazuddin@rungta.ac.in

DOI: 10.5958/0974-360X.2018.00539.5   

Address: Hemlata Sahu, Amit Alexander, Swapnil Gupta, Pooja Yadav, Hemlata Thapa, Tripti Banjare, Palak Agrawal, Akansha Bhandarkar, Aditi Bhatt, Shradha Devi Diwedi, Pankaj Sahu, Siddharth Kumar Sahu, Kailash Sahu, Deeksha Dewangan, Deepika, Mukesh Sharma, D. K. Tripathi, Ajazuddin*
Rungta College of Pharmaceutical Sciences and Research, Kohka-kurud Road, Bhilai, Chhattisgarh, 4900024.
*Corresponding Author

Published In:   Volume - 11,      Issue - 7,     Year - 2018


ABSTRACT:
Mouth dissolving oral films are useful in patients such as paediatric, geriatric, bedridden or developmentally disabled who face difficulty in swallowing conventional tablets or capsules and liquid orals or syrups leading to ineffective therapy. Mouthdissolving films have been played an important role in the current pharmaceutical research. They have convenience and ease of use over other dosage forms such as orally disintegrating tablets and immediate release tablets. Mouth dissolving films are oral solid dosage form that disintegrate and dissolve within a minute when placed in mouth without taking water or chewing. Risperidone is effective for treating the positive and negative symptoms of schizophrenia compared to first generation antipsychotics. But oral administration of Risperidone has drawbacks such as hepatic first pass metabolism which is overcome by means of mouth dissolving film.In the present research, mouthdissolving films of riseperidone were developed using low viscosity grades of HPMC K15 and sorbitol polymers and propylene glycol as plasticizer and purified water as solvent followed by solvent casting method. All films prepared were smooth and elegant in appearance and showed no visible cracks; were uniform in thickness, weight and drug content.


Cite this article:
Hemlata Sahu, Amit Alexander, Swapnil Gupta, Pooja Yadav, Hemlata Thapa, Tripti Banjare, Palak Agrawal, Akansha Bhandarkar, Aditi Bhatt, Shradha Devi Diwedi, Pankaj Sahu, Siddharth Kumar Sahu, Kailash Sahu, Deeksha Dewangan, Deepika, Mukesh Sharma, Research J. Pharm. and Tech 2018; 11(7): 2922-2925. D. K. Tripathi, Ajazuddin. Formulation and Evaluation of Risperidone Loaded Mouth-Dissolving Film. doi: 10.5958/0974-360X.2018.00539.5

Cite(Electronic):
Hemlata Sahu, Amit Alexander, Swapnil Gupta, Pooja Yadav, Hemlata Thapa, Tripti Banjare, Palak Agrawal, Akansha Bhandarkar, Aditi Bhatt, Shradha Devi Diwedi, Pankaj Sahu, Siddharth Kumar Sahu, Kailash Sahu, Deeksha Dewangan, Deepika, Mukesh Sharma, Research J. Pharm. and Tech 2018; 11(7): 2922-2925. D. K. Tripathi, Ajazuddin. Formulation and Evaluation of Risperidone Loaded Mouth-Dissolving Film. doi: 10.5958/0974-360X.2018.00539.5   Available on: https://rjptonline.org/AbstractView.aspx?PID=2018-11-7-38


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