Author(s): P. Jitendra kumar, Y. Indira Muzib, Gitanjali Misra

Email(s): pjksai@rediffmail.com

DOI: 10.5958/0974-360X.2018.00516.4   

Address: P. Jitendra kumar1*, Y. Indira Muzib2, Gitanjali Misra3
1Nalanda Institute of Pharmaceutical Sciences, Kantepudi, Sattenapalli, Guntur, Andhra Pradesh
2Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam, Tirupati 517501, Andhra Pradesh, India.
3Department of Zoology, Berhampur University, Brahampur 760007, Odisha, India.
*Corresponding Author

Published In:   Volume - 11,      Issue - 7,     Year - 2018


ABSTRACT:
In the present study, an attempt was made to develop the pulsatile drug delivery of Lovastatin to reduce plasma cholesterol levels and to prevent cardiovascular diseases. Formaldehyde treated Capsule bodies were used for the preparation of pulsincaps. It was sealed with unhardened cap of the capsule. The microspheres were prepared by emulsion solvent evaporation technique. Hydrogel plug (karaya gum and lactose in 1:1 ratio) having 4.5kg/cm2 hardness and 100 mg weight was placed in the capsule opening and found that it was satisfactory to retard the drug release in small intestinal fluid and to eject out the plug in colonic fluid and releasing the microspheres into colonic fluid after a lag time criterion of 5 hours.The sealed capsules were completely coated by dip coating method with 5% cellulose acetate phthalate to prevent variable gastric emptying. Optimized microsphere formulations were selected based on dissolution studies. Dissolution studies of pulsatile capsule device in media with different pH (1.2, 7.4 and6.8) showed that drug release in colon could be modulated by optimizing the concentration of polymers in the microspheres. Drug–polymer interaction studies indicated no interaction in between the drug and the polymer.Among all the formulations Lovastatin microspheres prepared with Ethyl cellulose, in 1:3 ratio shown prolonged release for a period of 11 hours.The obtained results showed the capability of the system in delaying drug release for a programmable period of time and to deliver the drug in the early morning hours when cholesterol synthesis are more prevalent.


Cite this article:
P. Jitendra kumar, Y. Indira Muzib, Gitanjali Misra. Formulation and Evaluation of Pulsatile Drug Delivery of Lovastatin. Research J. Pharm. and Tech 2018; 11(7): 2797-2803 doi: 10.5958/0974-360X.2018.00516.4

Cite(Electronic):
P. Jitendra kumar, Y. Indira Muzib, Gitanjali Misra. Formulation and Evaluation of Pulsatile Drug Delivery of Lovastatin. Research J. Pharm. and Tech 2018; 11(7): 2797-2803 doi: 10.5958/0974-360X.2018.00516.4   Available on: https://rjptonline.org/AbstractView.aspx?PID=2018-11-7-15


Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags


Not Available